83318-15-4

Basic information

• Product Name: N-(4-METHYLPHENYL)-1H-BENZIMIDAZOL-2-AMINE
• Synonyms: N-(4-METHYLPHENYL)-1H-BENZIMIDAZOL-2-AMINE
• CAS NO: 83318-15-4
• Molecular Formula: C₁₄H₁₃N₃
• Molecular Weight: 223.27312
• Mol File: 83318-15-4.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-METHYLPHENYL)-1H-BENZIMIDAZOL-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-METHYLPHENYL)-1H-BENZIMIDAZOL-2-AMINE(83318-15-4)
• EPA Substance Registry System: N-(4-METHYLPHENYL)-1H-BENZIMIDAZOL-2-AMINE(83318-15-4)

Safety Data

• Hazardous Substances Data: 83318-15-4(Hazardous Substances Data)

Upstream product

• 726-42-1 di-p-tolylcarbodiimide 
• 95-54-5 1,2-diamino-benzene 
• 13037-22-4 methyl (N-(4-methylphenyl))dithiocarbamate 
• 33141-99-0 dimethyl N-(4-methylphenyl)dithioimidocarbonate 
• 4857-06-1 2-chloro-1H-benzoimidazole 
• 106-49-0 p-toluidine 
• 412309-12-7 N-(2-amino-phenyl)-N'-p-tolyl-thiourea 
• 934-32-7 1H-benzimidazol-2-amine 
• 5720-05-8 4-methylphenylboronic acid 
• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 123375-81-5 N-(2-bromophenyl)guanidine 
• 624-31-7 4-tolyl iodide 
• 615-36-1 2-bromoaniline 

Downstream Products

• 1015077-17-4 C₂₀H₁₅N₅OS 

Relevant articles and documents

Microwave-assisted hydrogen peroxide-mediated synthesis of benzoxazoles and related heterocycles via cyclodesulfurization

A novel approach has been developed to construct benzoxazoles and similar N- and S-containing heterocycles from their corresponding isothiocyanates and o-substituted anilines via cyclodesulfurization. The reaction was found to proceed via in situ formatio

Copper-promoted one-pot approach: Synthesis of benzimidazoles

A facile, one-pot, and proficient method was developed for the production of various 2-arylaminobenzimidazoles. This methodology is based for the first time on a copper catalyst promoted domino C-N cross-coupling reaction for the generation of 2-arylaminobenzimidazoles. Mechanistic investigations revealed that the synthetic pathway involves a copper-based desulphurization/nucleophilic substitution and a subsequent domino intra and intermolecular C-N cross-coupling reactions. Some of the issues typically encountered during the synthesis of 2-arylaminobezimidazoles, including the use of expensive catalytic systems and the low reactivity of bromo precursors, were addressed using this newly developed copper-catalyzed method. The reaction procedure is simple, generally with excellent substrate tolerance, and provides good to high yields of the desired products.

Nickel-catalyzed Chan-Lam cross-coupling: Chemoselective: N -arylation of 2-aminobenzimidazoles

A complementary set of Ni- and Cu-based catalyst systems for the selective N-arylation of 2-aminobenzimidazoles have been developed. Selective N-arylation of the primary amine (C-NH2) group was achieved by Ni-catalyzed, boronic acid promoted cr