83318-25-6

Basic information

• Product Name: 2-(2-phenylethyl)-1,3-benzoxazole
• CAS NO: 83318-25-6
• Molecular Formula: C₁₅H₁₃NO
• Molecular Weight: 223.2698
• Mol File: 83318-25-6.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 354.5°C at 760 mmHg
• Flash Point: 146.8°C
• Density: 1.156g/cm³
• Vapor Pressure: 6.82E-05mmHg at 25°C
• Refractive Index: 1.627
• CAS DataBase Reference: 2-(2-phenylethyl)-1,3-benzoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-phenylethyl)-1,3-benzoxazole(83318-25-6)
• EPA Substance Registry System: 2-(2-phenylethyl)-1,3-benzoxazole(83318-25-6)

Safety Data

• Hazardous Substances Data: 83318-25-6(Hazardous Substances Data)

Usage

Chemical classification

Benzoxazole derivative

Structural feature

Contains a phenylethyl group attached to the benzene ring

Usage in organic synthesis

Commonly used in organic synthesis due to its unique structure

Pharmaceutical research

Possesses potential pharmacological activities

Potential applications

Treatment of various medical conditions, such as cancer and neurodegenerative diseases

Fluorescent properties

Investigated for its fluorescent properties, useful in materials science research

Diverse potential applications

Applicable in both pharmaceutical and materials research fields

Upstream product

• 95-21-6 2-methyl-1,3-benzoxazole 
• 100-44-7 benzyl chloride 
• 888-92-6 2-styrylbenzo[d]oxazole 
• 35321-17-6 2-(2-hydroxy-anilino)-4-phenyl-but-3-enenitrile 
• 122-97-4 3-Phenyl-1-propanol 
• 95-55-6 2-amino-phenol 
• 501-52-0 3-Phenylpropionic acid 
• 645-45-4 hydrocinnamic acid chloride 
• 273-53-0 benzoxazole 
• 103-63-9 1-phenyl-2-bromoethane 
• 1345514-56-8 C₁₅H₁₅NO 
• 3516-95-8 2'-hydroxy-3-phenylpropiophenone 
• 100-51-6 benzyl alcohol 
• 93-55-0 1-phenyl-propan-1-one 

Downstream Products

• 104655-31-4 2-Benzooxazol-2-yl-3-phenyl-propionaldehyde 
• 35491-31-7 rac-2-(benzoxazol-2-yl)-1-phenylethanol 

Relevant articles and documents

Manganese catalyzed C-alkylation of methylN-heteroarenes with primary alcohols

C-Alkylations of nine different classes of methyl-substitutedN-heteroarenes, including quinolines, quinoxalines, benzimidazoles, benzoxazoles, pyrazines, pyrimidines, pyridazines, pyridines, and triazines are disclosed. A bench stable earth-abundant Mn(i)-complex catalyzed the chemoselective hydrogen-transfer reaction utilizing a diverse range of primary alcohols as the non-fossil fuel-derived carbon source. The diversifiedN-heteroarenes (41 examples) were isolated in high yields and selectivities. Water is produced as the sole byproduct, making the protocol environmentally benign.

Transition-Metal-Free Alkylation/Arylation of Benzoxazole via Tf2O-Activated-Amide

A transition-metal-free approach to the alkylation/arylation of benzoxazole was developed by employing Tf2O-activated-amide as the alkylating/arylating reagent. The mild reaction conditions, and particularly insensitivity to air and water, further enhance the synthetic potential in pharmaceutical synthesis. (Figure presented.).

Elemental Sulfur-Promoted Oxidative Rearranging Coupling between o-Aminophenols and Ketones: A Synthesis of 2-Alkyl benzoxazoles under Mild Conditions

In the presence of N-methylpiperidine, elemental sulfur was found to act as excellent oxidant in promoting oxidative rearranging coupling between o-aminophenols and ketones. A wide range of 2-alkylbenzoxazoles was obtained under mild conditions.