83373-60-8 Usage
Description
D609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC; Ki = 6.4 μM). It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA2, or phospholipase D. D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations when used at concentrations of 100 and 200 mg/ml, respectively. Similar to other xanthates, D609 has antioxidant, antiviral, and anti-tumor activities. In addition, it has anti-inflammatory actions, inhibiting LPS-stimulated expression of nitric oxide synthase (NOS) in phagocytes (IC50 = 20 μg/ml) and IL-1β-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in endothelial cells.
Uses
Used in Biological Research:
D609 is used as a phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor for studying the role of PC-PLC in various biological processes.
Used in Mouse Bone Marrow Derived Monocytes:
D609 is used as a PC-PLC inhibitor in mouse bone marrow derived monocytes to investigate its effects on cellular functions.
Used in Apolipoprotein E-/Mice:
D609 is used to significantly reduce the elevated levels of phosphatidylethanolamine binding protein 1 (PEBP1) in apolipoprotein E-/mice, indicating its potential use in managing lipid metabolism related disorders.
Used in Antioxidant Applications:
D609 is used for its antioxidant properties, which can help protect cells from oxidative stress and damage.
Used in Antiviral Applications:
D609 is used for its antiviral activities, potentially inhibiting the replication and spread of viruses in host cells.
Used in Anti-tumor Applications:
D609 is used for its anti-tumor activities, which can help suppress tumor growth and progression.
Used in Anti-inflammatory Applications:
D609 is used for its anti-inflammatory actions, inhibiting LPS-stimulated expression of nitric oxide synthase (NOS) in phagocytes and IL-1β-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in endothelial cells. This can help in managing inflammation-related conditions.
Biological Activity
Selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (K i = 6.4 μ M); antiviral and antitumor agent. Suppresses LPS- and IFN γ -induced NO production (IC 50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo .
Biochem/physiol Actions
D609 can block the production of diacylglycerol (DAG) in the cell. D609 functions by inhibiting the phospholipase C-mediated hydrolysis of the phosphate bond present in phosphatidylcholine and other glycerophospholipids.
references
1. a) e. amtmann, drugs exp clin res 1996, 22, 287-294; b) r. m. adibhatla, j. f. hatcher and a. gusain, neurochem res 2012, 37, 671-679. 2. l. paris, s. cecchetti, f. spadaro, l. abalsamo, l. lugini, m. e. pisanu, e. iorio, p. g. natali, c. ramoni and f. podo, breast cancer res 2010, 12, r27. 3. a) k. tschaikowsky, m. meisner, f. schonhuber and e. rugheimer, br j pharmacol 1994, 113, 664-668; b) r. r. cobb, k. a. felts, g. c. parry and n. mackman, mol pharmacol 1996, 49, 998-1004.
Check Digit Verification of cas no
The CAS Registry Mumber 83373-60-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,3,7 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 83373-60:
(7*8)+(6*3)+(5*3)+(4*7)+(3*3)+(2*6)+(1*0)=138
138 % 10 = 8
So 83373-60-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H16OS2.K/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8;/h6-10H,1-5H2,(H,13,14);
