834-93-5

Basic information

• Product Name: 1-(2,4,5-trimethoxyphenyl)-1-propanol
• Synonyms: 1-(2,4,5-trimethoxyphenyl)-1-propanol
• CAS NO: 834-93-5
• Molecular Formula: C₁₂H₁₈O₄
• Molecular Weight: 226.26892
• Mol File: 834-93-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2,4,5-trimethoxyphenyl)-1-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4,5-trimethoxyphenyl)-1-propanol(834-93-5)
• EPA Substance Registry System: 1-(2,4,5-trimethoxyphenyl)-1-propanol(834-93-5)

Safety Data

• Hazardous Substances Data: 834-93-5(Hazardous Substances Data)

Usage

General Description

1-(2,4,5-trimethoxyphenyl)-1-propanol, also known as TMA-6, is a chemical compound that belongs to the phenethylamine class of psychoactive drugs. It is a synthetic substance that has been used for its hallucinogenic and psychedelic effects. TMA-6 is similar in structure to mescaline and produces similar effects, including visual and auditory distortions, altered perception of time and space, and sensory enhancement. It is commonly used as a recreational drug, and its use is associated with potential risks and adverse effects, including increased heart rate, elevated blood pressure, anxiety, and paranoia. TMA-6 is considered a controlled substance in many countries, and its use is illegal without a prescription.

Upstream product

• 830-79-5 2,4,6-trimethoxybenzaldehyde 
• 925-90-6 ethylmagnesium bromide 
• 74-96-4 ethyl bromide 
• 621-23-8 1,2,3-trimethoxybenzene 
• 123-38-6 propionaldehyde 

Downstream Products

• 5273-96-1 (E)-1,3,5-trimethoxy-2-(prop-1-en-1-yl)benzene 

Relevant articles and documents

The cooperative effect of Lewis pairs in the Friedel-Crafts hydroxyalkylation reaction: A simple and effective route for the synthesis of (±)-carbinoxamine

An efficient C-C bond formation strategy between aromatic/heteroaromatic π-nucleophiles and Lewis acid activated aldehydes is described. This aromatic electrophilic substitution reaction of arenes or heteroarenes is facilitated by Lewis acid AlBr3. Aromatic rings with electron donating substituents are excellent nucleophilic counterparts in this reaction, generating carbinols in excellent yields (61-94%). The formation of triarylmethanes is also witnessed in the case of certain reactive aldehydes and aromatic π-nucleophiles through reactive carbocation formation. The formation of triarylmethane is reduced to a greater extent via retardation of the second π-nucleophile addition through a Lewis base, for example, pyridine, coordination with an aluminium alkoxide intermediate. Various aliphatic aldehydes also underwent Friedel-Crafts type hydroxyalkylation and generated the expected carbinols in moderate yields (41-53%) in the presence of AlBr3. This protocol has been successfully applied to the synthesize of the (±)-carbinoxamine, a therapeutically important histamine H1 antagonist, in a one-pot manner.

Feeding-deterrent activity of α-asarone isomers against some stored Coleoptera

All isomers of α-asarone [(E)-4-prop-1-enyl-1,2,5-trimethoxybenzene] were tested for their feeding deterrent activity against adults of Sitophilus granarius and Tribolium confusum and larvae of Trogoderma granarium and Tribolium confusum. (E)-2-prop-1-eny

Crystal structures of 1,2,5-trimethoxy-3-(1-propenyl)benzene and 1,3,5-trimethoxy-2-(1-propenyl)benzene

The crystal structures of 1,2,5-trimethoxy-3-(1-propenyl)benzene (D) and 1,3,5-trimethoxy-2-(1-propenyl)benzene (F) have been determined by X-ray diffraction methods. The compounds crystallize in the monoclinic system, space group P21/c for (D)