83417-24-7 Usage
General Description
5-(Pyridin-2-ylmethyl)-4H-1,2,4-triazol-3-amine is a chemical compound that belongs to the group of triazole derivatives. As an organic compound, it includes multiple functional groups such as a pyridine ring, a triazole ring, and an amine group. Its structure allows it to interact with molecular targets in specific ways, making it potentially valuable in drug development. The compound's properties can be affected by factors such as its purity and storage conditions. Detailed Information about its toxicity, environmental impacts, and physiological effects is generally obtained through laboratory testing and analysis; specific data about this particular compound may not readily available or it may not have been thoroughly studied yet.
Check Digit Verification of cas no
The CAS Registry Mumber 83417-24-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,4,1 and 7 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 83417-24:
(7*8)+(6*3)+(5*4)+(4*1)+(3*7)+(2*2)+(1*4)=127
127 % 10 = 7
So 83417-24-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H9N5/c9-8-11-7(12-13-8)5-6-3-1-2-4-10-6/h1-4H,5H2,(H3,9,11,12,13)
83417-24-7Relevant articles and documents
Bioisosteric Design of Conformationally Restricted Pyridyltriazole Histamine H2-Receptor Antagonists
Lipinski, Christopher A.
, p. 1 - 6 (2007/10/02)
A process of bioisosteric drug design is described whereby, in a manner analogous to synthesis, key portions of an effector molecule are successively replaced by pharmacophores or bioisosteres.This process, when applied to histamine, leads to the competitive histamine H2-receptor antagonist prototype 3-amino-5-(2-amino-4-pyridyl)-1,2,4-triazole (7).The biaryl nature of 7 fixes internitrogen distances, and comparison of these with histamine suggests that 7 shares structural features more in common with histamine trans rather than histamine gauche conformations.Alkylation of the prototype pyridylamino group in 7 markedly improves both histamine H2-receptor antagonist and gastric acid antisecretory activity so that the resulting agent, 3-amino-5--1,2,4-triazole (8), is more active than cimetidine.
