83465-22-9Relevant articles and documents
Synthesis method of valiolamine key intermediate
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, (2019/02/04)
The invention relates to a synthesis method of a valiolamine key intermediate IV. According to the method, valiolamine is used as a raw material to prepare the key intermediate IV through amino protection, 4-site dydroxymethyl iodideo reaction, 1,2,3-site three-hydroxyl protection, hydrogen iodide removal and double-bond forming; the key intermediate IV can be used for synthesizing valiolamine.
Volt-voglibose intermediate and its preparation method
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, (2018/05/30)
The invention relates to a voglibose intermediate as shown in the following formula V and a preparation method of the voglibose intermediate and also relates to a preparation method of a voglibose intermediate 1L(1S)-(1(OH), 2, 4, 5/1, 3)-5-amino-1-C-(hydroxymethyl)-1, 2, 3, 4-tetrahydroxycyclohexane. The method comprises the steps: with a validamycin fermentation byproduct 1L(1, 3, 4/2)-4-amino-6-hydroxymethyl-1, 2, 3-trihydroxycyclohexane as a raw material, carrying out amino protection, elimination, epoxidation, hydrolysis and deprotection reaction to obtain valiolamine. Compared with the traditional synthesis method, the method disclosed by the invention is few in synthesis step, little in pollution due to the adoption of a recyclable efficient catalyst, simple in operation and stable in yield.
Improved Stereoselective Syntheses of (+)-Valiolamine and (+)-Valienamine Starting from (–)-Shikimic Acid
Li, Fenglei,Ding, Wei,Quan, Na,Wu, Jiajia,He, Yungang,Zhu, Xingliang,Shi, Xiaoxin,Zhao, Jianhong
, p. 457 - 464 (2017/04/28)
Improved stereoselective syntheses of the target compounds (+)-valiolamine 1 and (+)-valienamine 2 starting from naturally abundant (–)-shikimic acid are described. A common key intermediate compound 7 was first synthesized from (–)-shikimic acid in 9 steps. The compound 7 was then converted to (+)-valiolamine 1 in 3 steps, and was also converted to (+)-valienamine 2 in 4 steps. In summary, (+)-valiolamine 1 and (+)-valienamine 2 were synthesized from (–)-shikimic acid in 12 (or 13) steps in 40% and 39% overall yields, respectively. The present syntheses are more practical and might be important for the potential industrial preparations of pharmaceutically valuable (+)-valiolamine 1 and (+)-valienamine 2.