834881-63-9

Basic information

• Product Name: Carbamic acid, [2-[(2-nitrophenyl)amino]ethyl]-, 1,1-dimethylethyl ester
• CAS NO: 834881-63-9
• Molecular Formula: C13H19N3O4
• Molecular Weight: 281.312
• Mol File: 834881-63-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-[(2-nitrophenyl)amino]ethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-[(2-nitrophenyl)amino]ethyl]-, 1,1-dimethylethyl ester(834881-63-9)
• EPA Substance Registry System: Carbamic acid, [2-[(2-nitrophenyl)amino]ethyl]-, 1,1-dimethylethyl ester(834881-63-9)

Safety Data

• Hazardous Substances Data: 834881-63-9(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 51138-16-0 N-(2-nitrophenyl)ethylenediamine 
• 57260-73-8 N-BOC-1,2-diaminoethane 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 51138-16-0 N-(2-nitrophenyl)ethylenediamine 
• 834881-64-0 tert‐butyl (3‐((2‐aminophenyl)amino)ethyl)carbamate 
• 55661-34-2 2-Benzimidazol-1-ylethylamine 
• 101091-09-2 2-(2-phenyl-benzimidazol-1-yl)-ethylamine 
• 64928-55-8 3-(2-aminoethyl)-1H-benzimidazol-2-one hydrochloride 
• 64928-88-7 1‐(3‐aminoethyl)‐1,3‐dihydro‐2H‐benzo[d]imidazole‐2‐one 

Relevant articles and documents

Chemical modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2h-benzo[d]imidazole-2-one scaffold as a novel NLRP3 inhibitor

In the search for new chemical scaffolds able to afford NLRP3 inflammasome inhibitors, we used a pharmacophore-hybridization strategy by combining the structure of the acrylic acid derivative INF39 with the 1-(piperidin-4-yl)1,3-dihydro-2H-benzo[d]imidazole-2-one substructure present in HS203873, a recently identified NLRP3 binder. A series of differently modulated benzo[d]imidazole-2-one derivatives were designed and synthesised. The obtained compounds were screened in vitro to test their ability to inhibit NLRP3-dependent pyroptosis and IL-1β release in PMA-differentiated THP-1 cells stimulated with LPS/ATP. The selected compounds were evaluated for their ability to reduce the ATPase activity of human recombinant NLRP3 using a newly developed assay. From this screening, compounds 9, 13 and 18, able to concentration-dependently inhibit IL-1β release in LPS/ATP-stimulated human macrophages, emerged as the most promising NLRP3 inhibitors of the series. Computational simulations were applied for building the first complete model of the NLRP3 inactive state and for identifying possible binding sites available to the tested compounds. The analyses led us to suggest a mechanism of protein– ligand binding that might explain the activity of the compounds.

BENZIMIDAZOLE DERIVATIVES AS ITK INHIBITORS

The present disclosure is directed to certain inhibitors of kinases such as ITK, BLK, BMX, BTK, JAK3, TEC, TXK, HER2 (ERBB2), or HER4 (ERBB4), in particular ITK, pharmaceutical compositions comprising such compounds, and method of treating diseases mediated by such kinases.

Sulfonyldihydrobenzimidazolone compounds as 5-hydroxytryptamine-6 ligands

The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.