834888-63-0

Basic information

• Product Name: 5-Thiazolecarboxamide, 2-chloro-N-(2-chloro-6-methylphenyl)-N-[(4-methoxyphenyl)methyl]-
• CAS NO: 834888-63-0
• Molecular Formula: C19H16Cl2N2O2S
• Molecular Weight: 407.32
• Mol File: 834888-63-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 5-Thiazolecarboxamide, 2-chloro-N-(2-chloro-6-methylphenyl)-N-[(4-methoxyphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Thiazolecarboxamide, 2-chloro-N-(2-chloro-6-methylphenyl)-N-[(4-methoxyphenyl)methyl]-(834888-63-0)
• EPA Substance Registry System: 5-Thiazolecarboxamide, 2-chloro-N-(2-chloro-6-methylphenyl)-N-[(4-methoxyphenyl)methyl]-(834888-63-0)

Safety Data

• Hazardous Substances Data: 834888-63-0(Hazardous Substances Data)

Upstream product

• 302964-11-0 2-chloro-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide 
• 824-94-2 p-methoxybenzyl chloride 
• 40398-01-4 2-chloro-6-methylphenyl isocyanate 

Downstream Products

• 1450754-44-5 2-(6-(2-(3-(but-3-ynyl)-3H-diazirin-3-yl)ethylamino)-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 
• 1092368-33-6 2-amino-N-(2-chloro-6-methylphenyl)-N-(4-methoxybenzyl)thiazole-5-carboxamide 
• 1092368-41-6 N-(2-chloro-6-methylphenyl)-2-(3-methylisoxazol-5-ylamino)thiazole-5-carboxamide 
• 1092368-43-8 N-(2-chloro-6-methylphenyl)-2-(1-methyl-1H-pyrazol-3-ylamino)thiazole-5-carboxamide 
• 1092368-26-7 2-(3-bromophenylamino)-N-(2-chloro-6-methylphenyl)-N-(4-methoxybenzyl)thiazole-5-carboxamide 
• 302961-18-8 N-(2-chloro-6-methylphenyl)-2-[(2,6-dimethyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide 
• 302962-49-8 dasatanib 
• 302964-08-5 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 
• 1356493-84-9 C₃₀H₃₅ClN₁₀O₃S 
• 1356493-82-7 C₂₉H₃₇ClN₁₀O₄S 
• 910297-59-5 2-({6-[(2-aminoethyl)amino]-2-methylpyrimidin-4-yl}amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 

Relevant articles and documents

Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling

Less is more: A minimalist "clickable" photo-crosslinker (see scheme) was incorporated with numerous small-molecule kinase inhibitors. The resulting probes were used for both in vitro (cell lysates) and in situ (live cells) proteome profiling, for large-scale identification of their potential cellular kinase targets and shows improved outcomes over previous probes. Copyright

TYROSINE KINASE INHIBITORS CONTAINING A ZINC BINDING MOIETY

The present invention relates to tyrosine kinase inhibitors that contain a zinc-binding moiety and their use in the treatment of tyrosine related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.

Cyclic protein tyrosine kinase inhibitors

Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.