835-40-5

Basic information

• Product Name: 3-(2-METHYL-2-NITROPROPYL)INDOLE
• Synonyms: 3-(2-METHYL-2-NITROPROPYL)INDOLE;3-(2-METHYL-2-NITRO-PROPYL)-1H-INDOLE
• CAS NO: 835-40-5
• Molecular Formula: C12H14N2O2
• Molecular Weight: 218.25176
• Mol File: 835-40-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 404.7°C at 760 mmHg
• Flash Point: 198.5°C
• Appearance: /
• Density: 1.208g/cm³
• Vapor Pressure: 9.28E-07mmHg at 25°C
• Refractive Index: 1.618
• Solubility: CH2Cl2, CHCl3, EtOAc
• CAS DataBase Reference: 3-(2-METHYL-2-NITROPROPYL)INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-METHYL-2-NITROPROPYL)INDOLE(835-40-5)
• EPA Substance Registry System: 3-(2-METHYL-2-NITROPROPYL)INDOLE(835-40-5)

Safety Data

• Hazardous Substances Data: 835-40-5(Hazardous Substances Data)

Usage

Uses

3-(2-Methyl-2-nitropropyl)-1H-indole is an intermediate in the synthesis of Bucindolol (B689430) which is a high-affinity, competitive beta blocker used in the treatment of congestive heart failure and hypertension.

InChI:InChI=1/C12H14N2O2/c1-12(2,14(15)16)7-9-8-13-11-6-4-3-5-10(9)11/h3-6,8,13H,7H2,1-2H3

Upstream product

• 87-52-5 3-(Dimethylaminomethyl)indole 
• 79-46-9 2-nitropropane 

Downstream Products

• 304-53-0 [2-(1H-indol-3-yl)-1,1-dimethylethyl]amine 
• 77216-19-4 1-(2-ethyl-phenoxy)-3-(2-indol-3-yl-1,1-dimethyl-ethylamino)-propan-2-ol 
• 72742-63-3 2-[2-hydroxy-3-[[2-(3-indolyl)-1,1-dimethylethyl]amino]propoxy]benzamide 
• 72742-60-0 1-(Biphenyl-2-yloxy)-3-[2-(1H-indol-3-yl)-1,1-dimethyl-ethylamino]-propan-2-ol 
• 72742-66-6 1-[[2-(3-indolyl)-1,1-dimethylethyl]amino]-3-(2-nitrophenoxy)-2-propanol 
• 77216-37-6 1-[[2-(3-indolyl)-1,1-dimethylethyl]amino]-3-phenoxy-2-propanol 
• 77216-17-2 1-[[2-(3-indolyl)-1,1-dimethylethyl]amino]-3-(2-methylphenoxy)-2-propanol 
• 77216-38-7 1-(2-aminophenoxy)-3-[[2-(3-indolyl)-1,1-dimethylethyl]amino]-2-propanol 
• 72742-64-4 1-(2-fluorophenoxy)-3-[[2-(3-indolyl)-1,1-dimethylethyl]amino]-2-propanol 
• 77216-21-8 1-[[2-(1-methyl-3-indolyl)-1,1-dimethylethyl]amino]-3-(2-methylphenoxy)-2-propanol 
• 77216-31-0 1-[[2-(3-indolyl)-1,1-dimethylethyl]amino]-3-[2-(2-propenyl)phenoxy]-2-propanol 
• 77216-33-2 1-(2,3-dimethylphenoxy)-3-[[2-(3-indolyl)-1,1-dimethylethyl]amino]-2-propanol 
• 77216-34-3 1-(2,4-dimethylphenoxy)-3-[[2-(3-indolyl)-1,1-dimethylethyl]amino]-2-propanol 
• 77216-35-4 1-(2,6-dimethylphenoxy)-3-[[2-(3-indolyl)-1,1-dimethylethyl]amino]-2-propanol 

Relevant articles and documents

Catalytic and Enantioselective Control of the C–N Stereogenic Axis via the Pictet–Spengler Reaction

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