83578-21-6

Basic information

• Product Name: (S)-2-PYRIDYLTHIO CYSTEAMINE HYDROCHLORIDE
• Synonyms: (S)-2-PYRIDYLTHIO CYSTEAMINE HYDROCHLORIDE;S-(2-AMINOETHYL)DITHIO-2-PYRIDINE HYDROCHLORIDE;(S)-2-PyridylthiocysteamineHCl;S-(2-Aminoethyl)dithio-2-pyridine Hydrochloride, S-(2-Pyridylthio)cysteamine Hydrochloride;Pyridyldithioethylamine;2-(2-pyridinyldithio)ethylamine;2-PyridyldithioethylaMine hydrochloride;2-(2-(pyridin-2-yl)disulfanyl)ethanaMine hydrochloride
• CAS NO: 83578-21-6
• Molecular Formula: C₇H₁₀N₂S₂
• Molecular Weight: 222.76
• Product Categories: Nitric Oxide Reagents;Cross Linking Reagents;MTS & Sulfhydryl Active Reagents
• Mol File: 83578-21-6.mol
• Article Data: 22

Chemical Properties

• Melting Point: 124-126°C
• Boiling Point: 305.4 °C at 760 mmHg
• Flash Point: 138.5 °C
• Appearance: off-white solid
• Density: 1.26 g/cm³
• Vapor Pressure: 0.000825mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• PKA: 8.42±0.10(Predicted)
• CAS DataBase Reference: (S)-2-PYRIDYLTHIO CYSTEAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-PYRIDYLTHIO CYSTEAMINE HYDROCHLORIDE(83578-21-6)
• EPA Substance Registry System: (S)-2-PYRIDYLTHIO CYSTEAMINE HYDROCHLORIDE(83578-21-6)

Safety Data

• Hazardous Substances Data: 83578-21-6(Hazardous Substances Data)

Usage

Chemical Properties

Off-White SOlid

Uses

A cleavable cross-linking reagent

InChI:InChI=1/C7H10N2S2/c8-4-6-10-11-7-3-1-2-5-9-7/h1-3,5H,4,6,8H2

Upstream product

• 2127-03-9 2,2'-dipyridyldisulphide 
• 60-23-1 Cysteamine 
• 535943-48-7 tert-butyl N-[2-(2-pyridyldisulfanyl)ethyl]carbamate 
• 156-57-0 2-mercaptoethylamine hydrochloride 
• 56-17-7 cystamine dihydrochioride 

Downstream Products

• 108762-34-1 {2-phenyl-1-[2-(pyridin-2-yldisulfanyl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester 
• 108731-68-6 2-amino-3-phenyl-N-[2-(pyridin-2-yldisulfanyl)-ethyl]-propionamide 
• 1380328-62-0 3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-N-(2-(pyridin-2-yldisulfanyl)ethyl)benzamide 
• 112247-65-1 (+)-biotin N-2-(pyridin-2-yldisulfanyl)ethyl amide 

Relevant articles and documents

Ternary-responsive magnetic nanocarriers for targeted delivery of thiol-containing anticancer drugs

Cancer is currently the second leading cause of death in the world and one of the most serious challenges in medical therapy. Targeted nanocarrier systems potentially propose a solution to the severe side effects associated with direct drug delivery to the tumor cells (conventional chemotherapy). A novel multi (magnetic, thermo, pH and redox) responsive drug nanocarrier was successfully prepared through the grafting of poly(N-isopropylacrylamide-co-maleic anhydride-g-S-S-Py), fully characterized by various techniques and subsequently used for loading and targeted delivery of 6-mercaptopurine (6MP), a thiol containing anticancer drug. The in vitro drug release behavior of 6MP over 24 h was investigated in the presence of GSH (10 mM and 2 μM for simulating intra and extracellular conditions, respectively) under physiologic (37 °C, pH 7.4) and simulated cancerous tissue (40 °C, pH 5.3) conditions. The thermo, pH and redox responsive 6MP release ability of the developed nanocarriers was proved through the in vitro drug release study. The cell cytotoxicity study on the Raji (Burkitt lymphoma) cell line indicated efficient performance of multi-responsive 6MP-loaded nanocarriers. It was concluded that the newly developed multi-responsive nanocarriers have promising potential for targeting of thiol containing anticancer drugs to the tumor tissues.

The structural role of cholesterol in biological membranes

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Protein and mRNA Delivery Enabled by Cholesteryl-Based Biodegradable Lipidoid Nanoparticles

Developing safe and efficient delivery systems for therapeutic biomacromolecules is a long-standing challenge. Herein, we report a newly developed combinatorial library of cholesteryl-based disulfide bond-containing biodegradable cationic lipidoid nanoparticles. We have identified a subset of this library which is effective for protein and mRNA delivery in vitro and in vivo. These lipidoids showed comparable transfection efficacies but much lower cytotoxicities compared to the Lpf2k in vitro. In vivo studies in adult mice demonstrated the successful delivery of genome engineering protein and mRNA molecules in the skeletal muscle (via intramuscular injection), lung and spleen (via intravenous injection), and brain (via lateral ventricle infusion).

Thiol- And Disulfide-Containing Vancomycin Derivatives against Bacterial Resistance and Biofilm Formation

Antibiotic-resistant and biofilm-associated infections constitute a rapidly growing issue. Use of the last-resort antibiotic vancomycin is under threat due to the increasing appearance of vancomycin-resistant bacteria as well as the formation of biofilms. Herein, we report a series of novel vancomycin derivatives carrying thiol- and disulfide-containing moieties. The new compounds exhibited enhanced antibacterial activity against a broad range of bacterial strains, including vancomycin-resistant microbes and Gram-negative bacteria. Moreover, all obtained derivatives demonstrated improved antibiofilm formation activity against VanB-resistant Enterococcus compared to vancomycin. This work establishes a promising strategy for combating drug-resistant bacterial infections or disrupting biofilm formation and advances the knowledge on the structural optimization of antibiotics with sulfur-containing modifications.

Photo-thermal assistant penetration diagnosis and treatment type nanometer medicine (by machine translation)

The invention belongs to the technical field of biology, and particularly relates to a diagnosis and treatment drug for assisting in deep penetration of tumors by utilizing a photo-thermal effect. The in-situ released probe, under near-infrared illuminati