83639-14-9

Basic information

• Product Name: 2,4-di(p-chlorophenyl)-3-azabicyclo[3.3.1]nonan-9-one
• Synonyms: 2,4-di(p-chlorophenyl)-3-azabicyclo[3.3.1]nonan-9-one
• CAS NO: 83639-14-9
• Molecular Weight: 360.283
• Mol File: 83639-14-9.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 2,4-di(p-chlorophenyl)-3-azabicyclo[3.3.1]nonan-9-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-di(p-chlorophenyl)-3-azabicyclo[3.3.1]nonan-9-one(83639-14-9)
• EPA Substance Registry System: 2,4-di(p-chlorophenyl)-3-azabicyclo[3.3.1]nonan-9-one(83639-14-9)

Safety Data

• Hazardous Substances Data: 83639-14-9(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 83651-07-4 (1S,2S,4R,5R,9R)-2,4-Bis-(4-chloro-phenyl)-3-aza-bicyclo[3.3.1]nonan-9-ol 
• 1228657-82-6 C₂₁H₂₂Cl₂N₄S 
• 5706-80-9 4-chlorobenzaldehyde thiosemicarbazone 
• 1203965-30-3 C₂₇H₂₆Cl₂N₂O 
• 1203965-25-6 C₂₁H₂₁Cl₂NO 
• 74959-65-2 2-(4-chlorobenzylidene)-N-phenylhydrazinecarbothioamide 
• 1256636-89-1 2,4-bis(p-chlorophenyl)-3-azabicyclo[3.3.1]nonan-9-one N-isonicotinoylhydrazone 
• 147225-35-2 2,4-bis(4-chlorophenyl)-3-azabicyclo[3.3.1]nonan-9-one oxime 

Relevant articles and documents

Synthesis, characterization and antitumor activities of some novel thiazinones and thiosemicarbazones derivatives

Two series of thiazinone and thiosemicarbazone derivatives (1-12) were synthesized using 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-ones (ABNs) and 3–alkyl–2,6–diarylpiperidin–4–ones as the starting materials. The structures of newly synthesized compounds were established on the basis of FT–IR, NMR spectroscopy and mass spectrometry. From the spectroscopic data, we identified that the cyclization reaction of thioamide with dialkyl acetylenedicarboxylate selectively gives six membered methyl 2-(2-(2,4-disubstituted-3-azabicyclo[3.3.1]nonan-9-ylidene)hydrazinyl)-4-oxo-4H-1,3-thiazine-6-carboxylates (1-6). In order to investigate the antitumor activities of the synthesized compounds, in?vitro cytotoxicity studies were carried out using human prostate cancer cell lines. Tested compounds showed good/moderate activities against cancer cell lines and further investigation carried out by live/dead assay.

Synthesis, spectral, structural and biological studies of N-cyclohexyl-2-(2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9-ylidene)hydrazinecarbothioamide derivatives

Potential antimicrobial activities of azabicyclic skeleton based N-cyclohexyl-2-(2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9-ylidene)hydrazinecarbothioamides (6-10) was synthesized. The newly synthesized compounds were characterized by FT-IR, 1H NM

Synthesis and antibacterial, antifungal activities of some 2r,4c-diaryl-3-azabicyclo[3.3.1]nonan-9-one-4-aminobenzoyl hydrazones

A series of biologically active seven 2r, 4c-diaryl-3-azabicyclo[3.3.1] nonan-9-one-4-aminobenzoyl hydrazone derivatives have been synthesized in good yield. The structures of compounds have been established on the basis of IR, 1H, 13C NMR, and elemental analysis. The structure-activity relationships (SAR) have been studied by screening of antimicrobial activity over a representative panel of bacterial and fungal strains using two-fold serial dilution method. All these synthesized compounds exhibited significant activities against all bacterial and fungal strains. Springer Science+Business Media, LLC 2010.