837-11-6Relevant articles and documents
3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1
Hosoda, Shinnosuke,Hashimoto, Yuichi
, p. 5414 - 5418 (2008/02/13)
We designed and synthesized novel type 1 5α-reductase inhibitors by using 3,3-diphenylpentane skeleton as a substitute for the usual steroid skeleton. 4-(3-(4-(N-Methylacetamido)phenyl)pentan-3-yl)phenyl dibenzylcarbamate (11k) is a competitive 5α-reductase inhibitor with the IC50 value of 0.84 μM.
Process for preparing 2-(4'-hydroxyaryl)-2-(4'-aminoaryl)-propanes
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, (2008/06/13)
A process for preparing 2-(4'-hydroxyaryl)-2-(4'-aminoaryl)-propanes of the general formula STR1 wherein R represents a hydrogen or halogen atom or an alkyl, aryl, nitro, nitrile, acyl, acyloxy or amino group, R1 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, and R2 and R3, independently from each other, represent a hydrogen or halogen atom, a nitro group or an alkyl group having 1 to 4 carbon atoms, which comprises reacting (A) at least one isopropenyl phenol compound selected from the group consisting of isopropenyl phenol derivatives of the general formula STR2 wherein R is as defined, and di- to eicosa-mers of said isopropenyl phenol derivatives with (B) an aromatic amine of the general formula STR3 wherein R1 , R2 and R3 are as defined, in the presence of 0.00001 to 0.008 mole, per mole of said isopropenylphenol compound (A) calculated as a monomer, of a acid catalyst and in the presence or absence of a phenolic solvent.
