837-78-5

Basic information

• Product Name: 2,2,2-trifluoro-N-(naphthalen-1-yl)acetamide
• Synonyms: 2,2,2-Trifluoro-N-(1-naphthyl)acetamide; acetamide, 2,2,2-trifluoro-N-1-naphthalenyl-
• CAS NO: 837-78-5
• Molecular Formula: C₁₂H₈F₃NO
• Molecular Weight: 239.1932
• Mol File: 837-78-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 356.2°C at 760 mmHg
• Flash Point: 169.2°C
• Density: 1.382g/cm³
• Vapor Pressure: 2.98E-05mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: 2,2,2-trifluoro-N-(naphthalen-1-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoro-N-(naphthalen-1-yl)acetamide(837-78-5)
• EPA Substance Registry System: 2,2,2-trifluoro-N-(naphthalen-1-yl)acetamide(837-78-5)

Safety Data

• Hazardous Substances Data: 837-78-5(Hazardous Substances Data)

Usage

General Description

2,2,2-trifluoro-N-(naphthalen-1-yl)acetamide is a chemical compound with the molecular formula C12H9F3NO. It is a white solid with a molecular weight of 247.20 g/mol. 2,2,2-trifluoro-N-(naphthalen-1-yl)acetamide is often used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active molecules. Its structure consists of a trifluoromethyl group and a naphthalen-1-yl group attached to an acetamide moiety. The presence of the fluorine substituents makes this compound highly electronegative, which can affect its reactivity and properties in chemical reactions. Additionally, the naphthalene group provides aromatic properties to the molecule, making it suitable for certain chemical processes and applications.

Upstream product

• 134-32-7 1-amino-naphthalene 
• 407-25-0 trifluoroacetic anhydride 
• 96254-05-6 2-(trifluoroacetyloxy)pyridine 
• 354-38-1 2,2,2-trifluoroacetamide 
• 90-11-9 1-Bromonaphthalene 
• 90-14-2 1-Iodonaphthalene 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 78977-68-1 N-(γ-phenylallyl)-N-trifluoroacetyl-1-naphthylamine 
• 1001098-42-5 C₂₁H₁₆F₃NO 
• 22950-23-8 N-(2-propenyl)-1-naphthylamine 
• 22774-95-4 N-cinnamyl-α-naphthylamine 
• 112983-35-4 (+)-8,9-benzo-10-butyl-3-(R)-α-methylbenzyl-5-deazaflavin 
• 79630-21-0 4-methyl-N-(naphthalen-1-yl)benzamide 

Relevant articles and documents

Carbon-Carbon Bond Formation of Trifluoroacetyl Amides with Grignard Reagents via C(O)-CF3 Bond Cleavage

The reaction of trifluoroacetyl amides with Grignard reagent for the substitution of CF3 group with various alkyl or aryl groups is described. A variety of aryl, quinolin-8-yl, and (hetero)alkyl functional groups as well as F, Cl, and Br atoms are well tolerated. These moisture-stable and easily available trifluoroacetyl amides can be conveniently obtained and used as new versatile precursors for isocyanates. The control experiments show that the reaction proceeds via an isocyanate intermediate and/or alkoxide/amide dual anionic intermediate.

Copper-catalyzed synthesis of primary arylamines from aryl halides and 2,2,2-trifluoroacetamide

A catalytic method was developed to synthesize primary arylamines from the corresponding aryl bromides and iodides under mild conditions (yields = 80-99%). Crystalline 2,2,2-trifluoroacetamide was used as ammonia surrogate and CuI/N,N′-dimethyl ethylenediamine was used as catalyst to achieve the C-N cross-coupling.

SURFACE-MODIFIED NANOPARTICLES COMPRISING A CATIONIC COLORANT FOR USE IN COLOR FILTERS

Color filter comprising a surface-modified nanoparticle wherein a cationic colorant is covalently attached to the surface of said nanoparticle, a polymerizable mixture for making color filters, a surface-modified nanoparticle and its use.