837-83-2

Basic information

• Product Name: H-GLY-PRO-ALA-OH
• Synonyms: N-(1-glycyl-L-prolyl)-alanine;Collagenase-Substrate Test Substance (for quantitative Collagenase-Determination);Gly-L-Pro-L-Ala-OH;Gly-Pro-Ala-OH;Gly-Pro-L-Ala-OH;Glycylprolylalanine;NSC 97941;GLY-PRO-ALA
• CAS NO: 837-83-2
• Molecular Formula: C₁₀H₁₇N₃O₄
• Molecular Weight: 243.26
• EINECS: 212-654-6
• Mol File: 837-83-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 579.1 °C at 760 mmHg
• Flash Point: 304 °C
• Appearance: White/Powder
• Density: 1.330
• Vapor Pressure: 6.46E-15mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: −20°C
• Solubility: Methanol (Slightly, Heated), Water (Slightly, Sonicated)
• Stability: Hygroscopic
• BRN: 5288874
• CAS DataBase Reference: H-GLY-PRO-ALA-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-GLY-PRO-ALA-OH(837-83-2)
• EPA Substance Registry System: H-GLY-PRO-ALA-OH(837-83-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 837-83-2(Hazardous Substances Data)

Usage

Chemical Properties

Crystalline

Uses

H-Gly-Pro-Ala-OH is used in the preparation of preventive medicine improvement medicine of gingivitis.

InChI:InChI=1/C10H17N3O4/c1-6(10(16)17)12-9(15)7-3-2-4-13(7)8(14)5-11/h6-7H,2-5,11H2,1H3,(H,12,15)(H,16,17)

Synthetic route

L-alanin (56-41-7) + H-Gly-Pro-pNA (60189-43-7) → 4-nitro-aniline (100-01-6) + gly-pro-ala (837-83-2) + H-Gly-Pro-OH (704-15-4)

Conditions	Yield
With dipeptidyl peptidase IV In glycerol at 40℃;
With dipeptidyl peptidase IV In glycerol at 40℃; Rate constant; Kinetics; constant of partition;

gly-pro-ala (837-83-2) → L-alanin (56-41-7) + H-Gly-Pro-OH (704-15-4)

Conditions	Yield
at 37℃; for 0.166667h; 0.1 M Tris HCl buffer pH 8.0, X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis subsp. cremoris nTR;
at 37℃; for 0.166667h; Rate constant; 0.1 M Tris HCl buffer pH 8.0, X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis subsp. cremoris nTR; Km;

Upstream product

• 56-41-7 L-alanin 
• 60189-43-7 H-Gly-Pro-pNA 

Downstream Products

• 56-41-7 L-alanin 
• 704-15-4 H-Gly-Pro-OH 

Relevant articles and documents

Application of the dipeptidyl peptidase IV in formation of the peptide bond

-