83701-16-0 Usage
Description
Lithocholic-2,2,4,4-d4 acid is a labeled cholic acid derivative that serves as a TGR5 modulator. It is a synthetic compound commonly found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. This deuterium-labeled bile acid is utilized for research purposes, particularly in the study of bile acid metabolism and its role in various physiological processes.
Uses
Used in Pharmaceutical Research:
Lithocholic-2,2,4,4-d4 acid is used as a research tool for investigating the role of bile acids in drug metabolism and their interaction with the TGR5 receptor. Its stable isotope labeling allows for accurate tracking and quantification in biological systems, providing valuable insights into bile acid signaling pathways and their potential therapeutic applications.
Used in Metabolic Studies:
In the field of metabolism, Lithocholic-2,2,4,4-d4 acid is employed as a tracer compound to study the metabolism of bile acids in the liver and gastrointestinal tract. Its deuterium labeling enables researchers to differentiate between endogenous and exogenous bile acids, aiding in the understanding of bile acid synthesis, conjugation, and transport.
Used in Drug Development:
Lithocholic-2,2,4,4-d4 acid is utilized in the development of drugs targeting the TGR5 receptor, which is involved in various physiological processes, including glucose and energy homeostasis, as well as bile acid and lipid metabolism. Its use as a modulator helps in the identification and optimization of potential drug candidates with improved efficacy and safety profiles.
Used in Analytical Chemistry:
In analytical chemistry, Lithocholic-2,2,4,4-d4 acid serves as an internal standard for the quantification of bile acids in biological samples. Its stable isotope labeling ensures accurate and reliable measurements, which are crucial for the diagnosis and monitoring of various liver and gastrointestinal disorders related to bile acid metabolism.
Check Digit Verification of cas no
The CAS Registry Mumber 83701-16-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,7,0 and 1 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 83701-16:
(7*8)+(6*3)+(5*7)+(4*0)+(3*1)+(2*1)+(1*6)=120
120 % 10 = 0
So 83701-16-0 is a valid CAS Registry Number.
