837430-24-7

Basic information

• Product Name: 1,2,4-Triazolo[4,3-a]pyrazine, 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro- 3-(trifluoromethyl)-, (2E)-2-butenedioate (1:1)
• CAS NO: 837430-24-7
• Molecular Formula: C16H15F6N5O.C4H4O4
• Molecular Weight: 523.392
• Mol File: 837430-24-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,2,4-Triazolo[4,3-a]pyrazine, 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro- 3-(trifluoromethyl)-, (2E)-2-butenedioate (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Triazolo[4,3-a]pyrazine, 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro- 3-(trifluoromethyl)-, (2E)-2-butenedioate (1:1)(837430-24-7)
• EPA Substance Registry System: 1,2,4-Triazolo[4,3-a]pyrazine, 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro- 3-(trifluoromethyl)-, (2E)-2-butenedioate (1:1)(837430-24-7)

Safety Data

• Hazardous Substances Data: 837430-24-7(Hazardous Substances Data)

Upstream product

• 110-17-8 (2E)-but-2-enedioic acid 
• 486460-32-6 sitagliptin 

Relevant articles and documents

AMORPHOUS FORM OF SITAGLIPTIN SALTS

The present invention claims amorphous solid state forms of sitagliptin salts, processes for their preparation, and pharmaceutical compositions thereof. As salt forming anions are claimed: The maleate, fumarate, besylate, mesylate and succinate.

CRYSTALLINE SALTS OF SITAGLIPTIN

The present invention relates to crystalline monobasic, dibasic and tribasic acid addition salts of the dipeptidyl peptidase-IV inhibitor sitagliptin.

PROCESSES FOR THE PREPARATION OF SITAGLIPTIN AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

There is provided salts and polymorphs of sitagliptin, processes for the preparation thereof, and pharmaceutical compositions comprising the same.