83757-37-3Relevant articles and documents
New route for preparation of nitrosubstituted 1,2-phenylenediamines
Bella, Maros,Milata, Viktor
, p. 425 - 427 (2008)
(Chemical Equation Presented) 4-Nitrobenzoselenadiazole was methylated with dimethylsulphate to give corresponding 1-N-methyl-4-nitrobenzoselenadiazolium methylsulphate which after alkaline ring-opening afforded 1-N-methyl-3-nitro-1, 2-phenylenediamine in
SPIROHYDANTOIN TRICYCLIC CGRP RECEPTOR ANTAGONISTS
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Page/Page column 94, (2008/06/13)
Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B1, B2, B3, B4, D1, D2, E1, E2, E3, E4, E5, G1, G2, R6, T, U, V, W, X, Y and Z are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
o-Nitroaniline Derivatives. Part 11. 4- and 7-Amino-1H-benzimidazole 3-Oxides
Harvey, Ian W.,McFarlane Michael D.,Moody, David J.,Smith, David M.
, p. 1939 - 1944 (2007/10/02)
Of the two title compounds, the 4-amino isomer (1a) is easily obtained, either by reduction of the corresponding nitro compound, or in a five-step sequence from 2-nitro-1,3-phenylenediamine.The 7-amino isomer (1d) cannot be obtained by strictly analogous routes but it may be prepared in four steps from 2',3'-dinitroacetanilide.Attempts to cyanomethylate monoacylated 3-nitro-1,2-phenylenediamines (8) lead to 1-acyl-2,3-dihydro-4-nitrobenzimidazoles (10).
