83766-88-5

Basic information

• Product Name: 2-(tert-butoxy)pyridine
• Synonyms: 2-(tert-butoxy)pyridine
• CAS NO: 83766-88-5
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.20562
• Mol File: 83766-88-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 88°C/100mmHg(lit.)
• Appearance: /
• Density: 0.967±0.06 g/cm3(Predicted)
• Refractive Index: 1.4840 to 1.4880
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.25±0.12(Predicted)
• CAS DataBase Reference: 2-(tert-butoxy)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(tert-butoxy)pyridine(83766-88-5)
• EPA Substance Registry System: 2-(tert-butoxy)pyridine(83766-88-5)

Safety Data

• Hazardous Substances Data: 83766-88-5(Hazardous Substances Data)

Usage

General Description

2-(tert-butoxy)pyridine is a chemical compound with the molecular formula C11H15NO. It is a pyridine derivative with a tert-butoxy group attached to the second carbon atom of the pyridine ring. 2-(tert-butoxy)pyridine is commonly used in organic synthesis as a reagent for various chemical reactions, such as oxidation and substitution reactions. It has also been studied for its potential biological and pharmaceutical applications, including its use as a ligand in coordination chemistry and as a precursor in the synthesis of pharmaceutical compounds. Additionally, 2-(tert-butoxy)pyridine may have applications in materials science, particularly in the development of new organic semiconductors and optoelectronic devices.

Upstream product

• 110-86-1 pyridine 
• 372-48-5 2-fluoropyridine 
• 865-47-4 potassium tert-butylate 
• 109-09-1 2-chloropyridine 

Downstream Products

• 142-08-5 2-Pyridone 
• 115-11-7 isobutene 
• 774-65-2 benzoic acid tert-butyl ester 
• 13756-42-8 tert-butyl 4-methylbenzoate 
• 16537-18-1 tert-butyl 2-methylbenzoate 
• 833-79-4 t-butyl 4-methoxybenzoate 
• 58656-97-6 tert-butyl meta-methoxybenzoate 
• 712-95-8 tert-butyl 4-chlorobenzoate 
• 16537-17-0 3-chlorobenzoic acid tert-butyl ester 
• 69038-74-0 tert-butyl 3-bromobenzoate 
• 19756-72-0 tert-butyl 4-nitrobenzoate 
• 105580-41-4 4-acetylbenzoic acid tert-butyl ester 
• 16537-09-0 t-butyl phenylacetate 
• 16537-10-3 tert-butyl 3-phenylpropanoate 

Relevant articles and documents

Heterocyclic compound as well as preparation method and application thereof

The invention discloses a heterocyclic compound and a preparation method and application thereof. The invention provides a heterocyclic compound as shown in a formula I or pharmaceutically acceptable salt thereof. The compound has the function of inhibiting the activity of PU.1, and can inhibit the transcriptional activity based on liver cell PU.1 dependence and inhibit fibrosis development.

Acid- and isobutylene-free synthesis of t-butyl ethers by in situ formation of 2-t-butoxy-1-methylpyridinium triflate

The title reagent is formed in situ by alkylation of 2-t-butoxypyrine. The subsequent addition of an alcohol substrate leads to the formation of t-butyl ethers without the need for isobutylene gas or acid activators.

The Mechanisms of Thermal Eliminations. Part 11. Rate Data for Pyrolysis of 2-Alkoxypyridines to 2-Pyridone, and of 2-Ethoxypicolines to 2-Picolones: Nature and Polarity of the Transition State

The rates of thermal elimination of 2-ethoxy-, 2-isopropoxy-, 2-t-butoxy-pyridine to 2-pyridone and the corresponding alkene, and of the 2-ethoxy derivatives of 3-, 4-, 5-, and 6-methylpyridines to ethylene and the corresponding 2-picolines have been measured over at least 50 deg for each compound, between 585.1 and 721.1 K.The respective log (A/s-1) and Ea/kJ mol-1 values for the former three compounds are 12.20, 196.5; 12.68, 187.6; and 12.33, 161.0, and these are similar to those for the corresponding acetates.The relative rates of the first-order unimolecular decomposition at 600 K are: Et(1.0), Pri(18.0), But(1645) compared with 1.0:28.8:3316 for the acetates.The polarity of the transition state is thus less than for ester elimination.The difference in the rate ratios k(Pri)/k(Et) for alkoxypyridine and acetate pyrolyses is greater than the difference in the k(But)/k(Pri) ratios and is interpreted in terms of the difference in polarity of the transition states for primary, secondary, and tertiary elimination.Methyl substituents in the 3-, 4-, 5-, and 6-positions of the pyridine ring change the rate at 600 K by factors of 1.57, 1.02, 0.74, and 1.08, respectively.These show the decomposition does not take place via N-alkylpyridone tautomers, and that the reaction is, like ester pyrolysis, sterically accelerated.