83767-49-1

Basic information

• Product Name: Piperazine, 1-(3-chloropropyl)-4-(3-methoxyphenyl)-
• CAS NO: 83767-49-1
• Molecular Formula: C14H21ClN2O
• Molecular Weight: 268.787
• Mol File: 83767-49-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Piperazine, 1-(3-chloropropyl)-4-(3-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(3-chloropropyl)-4-(3-methoxyphenyl)-(83767-49-1)
• EPA Substance Registry System: Piperazine, 1-(3-chloropropyl)-4-(3-methoxyphenyl)-(83767-49-1)

Safety Data

• Hazardous Substances Data: 83767-49-1(Hazardous Substances Data)

Upstream product

• 109-70-6 1.3-chlorobromopropane 
• 16015-71-7 4-(3-methoxyphenyl)piperazine 
• 16015-70-6 4-(3-methoxyphenyl) piperazine hydrochloride 

Downstream Products

• 91532-16-0 3-{3-[4-(3-Methoxy-phenyl)-piperazin-1-yl]-propyl}-3H-benzo[d][1,2,3]triazin-4-one 
• 84344-56-9 1-(4-nitrophenoxy)-3-1-(N⁴-(3-methoxyphenyl)piperazinyl)>propane 
• 1034265-95-6 C₂₁H₂₉N₃O₄S 

Relevant articles and documents

Design, synthesis, and biological evaluation of structurally constrained hybrid analogues containing ropinirole moiety as a novel class of potent and selective dopamine D3 receptor ligands

Two series of hybrid analogues were designed, synthesized, and evaluated as a novel class of selective ligands for the dopamine D3 receptor. Binding affinities of target compounds were determined (using the method of radioligand binding assay). Compared to comparator agent BP897, compounds 2a and 2c were found to demonstrate a considerable binding affinity and selectivity for D3 receptor, and especially compound 2h was similarly potent and more selective D3R ligand than BP897, a positive reference. Thus, they may provide valuable information for the discovery and development of highly potent dopamine D3 receptor ligands with outstanding selectivity.

Microwave-assisted solvent-free synthesis of 3-[(4-substituted piperazin-1-yl)alkyl] imidazo[2,1-b][1,3]benzothiazol-2(3H)-ones as serotonin3 (5-HT3) receptor antagonists

A series of novel 3-[(4-substituted piperazin-1-yl)alkyl]imidazo[2,1-b][1, 3]benzothiazol-2(3H)-ones were prepared by microwave irradiation using alumina as solid support and also by a conventional method. The compounds were characterized by spectral data and the purity was ascertained by microanalysis. The synthesized compounds were evaluated for 5-hydroxytryptamine3 antagonisms in a longitudinal muscle-myenteric plexus preparation from guinea pig ileum against the 5-hydroxytryptamine3 agonist, 2-methyl-5-hydroxytryptamine. Among the test compounds, 3-[2-(4-methylpiperazin- 1-yl)ethyl]imidazo[2,1-6][1,3]benzothiazol-2(3H)-one (3b) showed most favorable 5-hydroxytryptamine3 antagonism (pA2 6.7) in the isolated guinea pig ileum.