83773-73-3Relevant articles and documents
2,4-Diamino-6,7-dimethoxyquinazolines. 3. 2-(4-Heterocyclylpiperazin-1-yl) Derivatives as α1-Adrenoceptor Antagonists and Antihypertensive Agents
Campbell, Simon F.,Plews, Rhona M.
, p. 1794 - 1798 (1987)
A series of 4-amino-6,7-dimethoxy-2-(4-heterocyclylpiperazin-1-yl)quinazolines (3) was prepared and screened for α-adrenoceptor affinity and antihypertensive activity.These quinazoline derivatives showed high binding affinity (ca. 10-10 M) and