83783-33-9

Basic information

• Product Name: 3-FORMYL-1H-INDOLE-6-CARBONITRILE
• Synonyms: 3-FORMYL-1H-INDOLE-6-CARBONITRILE;3-ForMyl-6-cyano-1H-indole;1H-Indole-6-carbonitrile, 3-formyl-
• CAS NO: 83783-33-9
• Molecular Formula: C₁₀H₆N₂O
• Molecular Weight: 170.17
• Mol File: 83783-33-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 429.6±25.0 °C(Predicted)
• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 13.67±0.30(Predicted)
• CAS DataBase Reference: 3-FORMYL-1H-INDOLE-6-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FORMYL-1H-INDOLE-6-CARBONITRILE(83783-33-9)
• EPA Substance Registry System: 3-FORMYL-1H-INDOLE-6-CARBONITRILE(83783-33-9)

Safety Data

• Hazardous Substances Data: 83783-33-9(Hazardous Substances Data)

Usage

General Description

3-FORMYL-1H-INDOLE-6-CARBONITRILE is a chemical compound with the molecular formula C10H6N2O and a molecular weight of 170.17 g/mol. It is a formylindole derivative with a carbonitrile functional group attached to the 6 position of the indole ring. 3-FORMYL-1H-INDOLE-6-CARBONITRILE is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various biologically active molecules, including potential drug candidates. It exhibits a yellowish-brown crystalline appearance and has a melting point of approximately 183-187°C. Its precise chemical properties and potential applications are subject to ongoing research and development.

Upstream product

• 15861-36-6 1H-Indole-6-carbonitrile 
• 68-12-2 N,N-dimethyl-formamide 
• 100-61-8 N-methylaniline 

Downstream Products

• 174500-88-0 6-cyano-1H-indole-3-carboxylic acid 
• 468718-26-5 3-formyl-1-(4-toluenesulfonyl)-1H-indole-6-carbonitrile 
• 468718-27-6 trans-3-[6-cyano-1-(4-toluenesulfonyl)-1H-indol-3-yl]-N-methoxy-N-methylacrylamide 
• 1428968-76-6 3-(2-((2-methoxypyridin-4-yl)amino)-2-phenylacetyl)-1H-indole-6-carbonitrile 
• 1428968-77-7 3-(2-((3-methoxyphenyl)amino)-2-phenylacetyl)-1H-indole-6-carbonitrile 

Relevant articles and documents

COMPOSITIONS COMPRISING THIENOPYRIMIDINE AND THIENOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF

The present invention relates generally to thienopyrimidine and thienopyridine class compounds and methods of use thereof. In particular embodiments, the present invention provides compositions comprising thienopyrimidine class compounds and methods of us

Mild and selective Ru-catalyzed formylation and Fe-catalyzed acylation of free (N-H) indoles using anilines as the carbonyl source

C3-selective formylation and acylation of free (N-H) indoles under mild conditions can be achieved by using Ru- and Fe-catalyzed oxidative coupling of free (N-H) indoles with anilines, respectively. Both processes are operationally simple, compatible with a variety of functional groups and generally provide the desired products in good yields. 13C-labeling experiments unambiguously established that the carbonylic carbon in the formylation products originated from methyl group of N-methyl aniline.

COMPOUNDS

The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.