83803-57-0

Basic information

• Product Name: 3-bromo-6-chloro-2-methoxytoluene
• Synonyms: 3-bromo-6-chloro-2-methoxytoluene;5-Bromo-2-chloro-4-methoxy-1-methylbenzene;Einecs 280-876-0
• CAS NO: 83803-57-0
• Molecular Formula: C₈H₈BrClO
• Molecular Weight: 235.50552
• EINECS: 280-876-0
• Mol File: 83803-57-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 252.3°C at 760 mmHg
• Flash Point: 106.4°C
• Appearance: /
• Density: 1.492g/cm³
• Vapor Pressure: 0.031mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: 3-bromo-6-chloro-2-methoxytoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-6-chloro-2-methoxytoluene(83803-57-0)
• EPA Substance Registry System: 3-bromo-6-chloro-2-methoxytoluene(83803-57-0)

Safety Data

• Hazardous Substances Data: 83803-57-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H8BrClO/c1-5-7(10)4-3-6(9)8(5)11-2/h3-4H,1-2H3

Upstream product

• 54788-38-4 2-chloro-4-methoxy-1-methylbenzene 
• 124-41-4 sodium methylate 
• 200190-87-0 3-bromo-6-chloro-4-fluoro-toluene 
• 67-56-1 methanol 

Downstream Products

• 1033723-30-6 1-bromo-(5-bromomethyl)-4-chloro-2-methoxybenzene 
• 1175754-49-0 2-bromo-5-chloro-4-methylphenol 
• 1360540-41-5 (4-chloro-2-hydroxy-5-methylphenyl)[3-(1,3-dioxolan-2-yl)phenyl]methanone 
• 1360540-42-6 ethyl {7-chloro-4-[3-(1,3-dioxolan-2-yl)phenyl]-6-methyl-2-oxo-2H-chromen-3-yl}acetate 
• 566945-76-4 [7-chloro-4-(3-formylphenyl)-6-methyl-2-oxo-2H-chromen-3-yl]acetic acid 
• 566945-80-0 2-[7-chloro-4-(3-formylphenyl)-6-methyl-2-oxo-2H-chromen-3-yl]-N-[4-fluoro-2-(trifluoromethyl)phenyl]acetamide 
• 566945-78-6 2-[7-chloro-4-(3-formylphenyl)-6-methyl-2-oxo-2H-chromen-3-yl]-N-[4-chloro-2-(trifluoromethyl)phenyl]acetamide 
• 566944-27-2 3-[7-chloro-3-[2-[[4-fluoro-2-(trifluoromethyl)phenyl]amino]-2-oxoethyl]-6-methyl-2-oxo-2H-chromen-4-yl]benzoic acid 
• 566944-76-1 ethyl (2E,4E)-5-{3-[7-chloro-3-(2-{[4-fluoro-2-(trifluoromethyl)phenyl]amino}-2-oxoethyl)-6-methyl-2-oxo-2H-chromen-4-yl]phenyl}-2,4-pentadienoate 
• 566945-08-2 (2E)-3-{3-[7-chloro-3-(2-{[4-fluoro-2-(trifluoromethyl)phenyl]amino}-2-oxoethyl)-6-methyl-2-oxo-2H-chromen-4-yl]phenyl}-2-methylacrylic acid 
• 566944-99-8 (2E,4E)-5-{3-[7-chloro-3-(2-{[4-fluoro-2-(trifluoromethyl)phenyl]amino}-2-oxoethyl)-6-methyl-2-oxo-2H-chromen-4-yl]phenyl}-2,4-pentadienoic acid 
• 566944-74-9 methyl [3-[7-chloro-3-[2-[[4-fluoro-2-(trifluoromethyl)phenyl]amino]-2-oxoethyl]-6-methyl-2-oxo-2H-chromen-4-yl]phenyl]acetate 
• 1226452-12-5 [3-[7-chloro-3-[2-[[4-fluoro-2-(trifluoromethyl)phenyl]amino]-2-oxoethyl]-6-methyl-2-oxo-2H-chromen-4-yl]phenyl]acetic acid 

Relevant articles and documents

5-[3-[PIPERIDIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS

The present invention discloses 5-[3-[piperazin-l-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives according to Formula (I), wherein R1, R2, R3a, R3b, R6a, R6b, the subscript n and Cy are as defined herein. The present invention relates to compounds inhibiting ADAMTS 4 and 5 for the prophylaxis or treatment of inflammatory diseases or diseases involving degradation of cartilage or disruption of cartilage homeostasis, such as e.g. osteoarthritis.

Discovery of a novel acyl-CoA: Cholesterol acyltransferase inhibitor: The synthesis, biological evaluation, and reduced adrenal toxicity of (4-phenylcoumarin)acetanilide derivatives with a carboxylic acid moiety

As a part of our research for novel potent and orally available acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors that can be used as anti-atherosclerotic agents, we recently reported the discovery of the (4-phenylcoumarine) acetanilide derivative 1. However, compound 1 showed adrenal toxicity in animal models. In order to search for safer ACAT inhibitors that do not have adrenal toxicity, we examined the inhibitory activity of ACAT in human macrophage and adrenal cells. The introduction of a carboxylic acid moiety on the pendant phenyl ring and the adjustment of the lipophilicity led to the discovery of (2E)-3-[7-chloro-3-[2-[[4-fluoro-2-(trifluoromethyl) phenyl]amino]-2-oxoethyl]-6-methyl-2-oxo-2H-chromen-4-yl]phenyl]acrylic acid (21e), which showed potent ACAT inhibitory activity in macrophages and a selectivity of around 30-fold over adrenal cells. In addition, compound 21e showed high adrenal safety in guinea pigs.