83817-51-0

Basic information

• Product Name: ethyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate
• Synonyms: ethyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate;3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxylic acid ethyl ester;Einecs 280-951-8
• CAS NO: 83817-51-0
• Molecular Formula: C₁₃H₁₁ClFNO₃
• Molecular Weight: 283.6827432
• EINECS: 280-951-8
• Mol File: 83817-51-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 372.9°C at 760 mmHg
• Flash Point: 179.3°C
• Appearance: /
• Density: 1.303g/cm³
• Vapor Pressure: 9.33E-06mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: ethyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate(83817-51-0)
• EPA Substance Registry System: ethyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate(83817-51-0)

Safety Data

• Hazardous Substances Data: 83817-51-0(Hazardous Substances Data)

Usage

Description

Ethyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate is a chemical compound that serves as a key intermediate in the synthesis of Flucloxacillin (F419200), a semisynthetic penicillin antibiotic with a broad spectrum of antibacterial activity.

Uses

Used in Pharmaceutical Industry:
Ethyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate is used as a chemical intermediate for the synthesis of Flucloxacillin (F419200), a semisynthetic penicillin antibiotic. This antibiotic possesses a broad spectrum of antibacterial activity, making it effective against a wide range of bacterial infections. Its synthesis involves the use of this ethyl ester derivative, which plays a crucial role in the development of this potent antibiotic.

InChI:InChI=1/C13H11ClFNO3/c1-3-18-13(17)10-7(2)19-16-12(10)11-8(14)5-4-6-9(11)15/h4-6H,3H2,1-2H3

Upstream product

• 387-45-1 2-chloro-6-fluorobenzaldehyde 
• 51088-25-6 2-chloro-6-fluoro-N-hydroxybenzene-1-carbonimidoyl chloride 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 1391943-03-5 (E)-N-[(2-chloro-6-fluorophenyl)methylidene]hydroxylamine 
• 443-33-4 N-[(2-chloro-6-fluorophenyl)methylidene]hydroxylamine 
• 70526-06-6 (Z)-3-pyrrolidin-1-yl-but-2-enoic acid ethyl ester 

Downstream Products

• 3919-74-2 3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid 
• 175204-42-9 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbothioamide 

Relevant articles and documents

1-(4-(ISOXAZOL-5-YL)-1H-PYRAZOL-1-YL)-2-METHYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS IL-17 AND IFN-GAMMA INHIBITORS FOR TREATING AUTOIMMUNE DISEASES AND CHRONIC INFLAMMATION

The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein Ar, Z and Y are as described herein and R1 is a group of the structure (formula (II)), wherein n is 0 or 1; R2 is H, deuterium or methyl; R3 is methyl, trilluoromethyl, ethyl, or taken with R2 together forms a cyclopropyl group, or R3 forms a methylene bridge to the carbon atom marked *, which are suitable for the treatment of autoimmune diseases and chronic inflammation.

IL17 AND IFN-GAMMA INHIBITION FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATION

The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salt or solvate thereof, as anti-inflammatory and immunomodulatory agents.