83846-84-8

Basic information

• Product Name: methyl 3-carboxy-1-methyl-1H-pyrrole-2-acetate
• Synonyms: methyl 3-carboxy-1-methyl-1H-pyrrole-2-acetate;2-(Methoxycarbonylmethyl)-1-methyl-1H-pyrrole-3-carboxylic acid;Einecs 281-063-3
• CAS NO: 83846-84-8
• Molecular Formula: C9H11NO4
• Molecular Weight: 197.18794
• EINECS: 281-063-3
• Mol File: 83846-84-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 340°C at 760 mmHg
• Flash Point: 159.4°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 3.44E-05mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: methyl 3-carboxy-1-methyl-1H-pyrrole-2-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-carboxy-1-methyl-1H-pyrrole-2-acetate(83846-84-8)
• EPA Substance Registry System: methyl 3-carboxy-1-methyl-1H-pyrrole-2-acetate(83846-84-8)

Safety Data

• Hazardous Substances Data: 83846-84-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11NO4/c1-10-4-3-6(9(12)13)7(10)5-8(11)14-2/h3-4H,5H2,1-2H3,(H,12,13)

Upstream product

• 67-56-1 methanol 
• 83863-74-5 2-(carboxymethyl)-1-methyl-1H-pyrrole-3-carboxylic acid 

Relevant articles and documents

Synthetic method of non-steroidal antiinflammatory drug pain killing

The invention discloses a synthesis method of non-steroidal anti-inflammatory drug tolmetin. The methodcomprises the following steps: sequentially preparing a sulfuric acid-containing acetonedicarboxylic acid crude product, 2-(2-acetoxy)-1-methyl-1H-pyrrole-3-formic acid and 2-(2-alkyl acetate)-1-methyl-1H-pyrrole-3-formic acid by taking citric acid or citric acid monohydrate as a raw material; and carrying out decarboxylation, acylation, hydrolysis and acidification to obtain tolmetin. The synthetic method provided by the invention overcomes the defect that the existing tolmetin preparation process depends on N-methylpyrrole, and is a low-cost, low-pollution and high-yield synthetic method of non-steroidal anti-inflammatory drug tolmetin.