83907-40-8 Usage
Description
6-methoxy-N-(3-sulfopropyl)quinolinium, also known as SPQ, is a fluorescent chloride indicator. It is an off-white to tan crystalline solid that exhibits excitation maxima of 320 and 350 nm and an emission maximum of 445 nm. SPQ's fluorescence is rapidly quenched by chloride in vitro, making it a useful tool for examining and measuring membrane chloride transport mechanisms.
Uses
Used in Biological Research:
6-methoxy-N-(3-sulfopropyl)quinolinium is used as a fluorescent chloride indicator for assessing voltage-sensitive chloride transport in placental microvillus vesicles. It helps in understanding the mechanisms of chloride transport across biological membranes.
Used in Cellular Analysis:
In isolated human erythrocytes, SPQ is used as a tool to continuously quantify intracellular calcium efflux induced by parathyroid hormone, forskolin, and phorbol 12-myristate 13-acetate (PMA). This application aids in studying the effects of these agents on cellular calcium regulation.
Used in Ion Channel Research:
6-methoxy-N-(3-sulfopropyl)quinolinium is utilized to determine the type of ion conductance induced by the cystic fibrosis transmembrane conductance regulator (CFTR) in HEK293 cells expressing pTrial10-CRTR2. This application is valuable for investigating the function and regulation of ion channels, particularly in the context of cystic fibrosis.
Check Digit Verification of cas no
The CAS Registry Mumber 83907-40-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,9,0 and 7 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 83907-40:
(7*8)+(6*3)+(5*9)+(4*0)+(3*7)+(2*4)+(1*0)=148
148 % 10 = 8
So 83907-40-8 is a valid CAS Registry Number.
InChI:InChI=1/C13H15NO4S/c1-18-12-5-6-13-11(10-12)4-2-7-14(13)8-3-9-19(15,16)17/h2,4-7,10H,3,8-9H2,1H3
83907-40-8Relevant articles and documents
Microwave assisted sulfopropylation of N-heterocycles using 1,3-propane sultone
Adamczyk, Maciej,Rege, Sushil
, p. 9587 - 9588 (2007/10/03)
Dramatic rate acceleration was observed for N-sulfopropylation of heterocyclic compounds (1a-h) using 1,3-propane sultone(2) under microwave irradiation affording the N-sulfopropylated compounds (3a-h) in 68-95% yield.
