83922-51-4

Basic information

• Product Name: N-(3-Bromophenyl)methansulfonamide
• Synonyms: N-(3-Bromophenyl)methansulfonamide
• CAS NO: 83922-51-4
• Molecular Formula: C₇H₈BrNO₂S
• Molecular Weight: 250.11
• Product Categories: Aryl;Building Blocks
• Mol File: 83922-51-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 330.7±44.0 °C(Predicted)
• Appearance: /
• Density: 1.711±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 7.47±0.10(Predicted)
• CAS DataBase Reference: N-(3-Bromophenyl)methansulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-Bromophenyl)methansulfonamide(83922-51-4)
• EPA Substance Registry System: N-(3-Bromophenyl)methansulfonamide(83922-51-4)

Safety Data

• Hazardous Substances Data: 83922-51-4(Hazardous Substances Data)

Usage

General Description

N-(3-Bromophenyl)methansulfonamide, also known as 3-Bromobenzenesulfonamide, is an organic compound with the chemical formula C7H8BrNO2S. It is a sulfonamide derivative, containing a sulfonamide group attached to a 3-bromophenyl group. N-(3-Bromophenyl)methansulfonamide is commonly used in medicinal chemistry as a building block for the synthesis of various pharmaceuticals and biologically active molecules. It exhibits anti-inflammatory and analgesic properties, making it a potential candidate for the development of new drugs for the treatment of inflammatory and pain-related conditions. Additionally, it may also be used as a reagent in organic synthesis for the modification of other molecules.

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 591-19-5 m-Bromoaniline 

Downstream Products

• 4964-71-0 5-bromoquinoline 
• 305448-92-4 N-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide 
• 875917-18-3 N-(3-bromophenyl)-N-methylmethanesulfonamide 
• 597561-37-0 N-(3-cyanophenyl)-N-methylmethanesulfonamide 
• 1314806-76-2 N-(3-ethynylphenyl)-N-methylmethanesulfonamide 
• 1314806-75-1 C₁₃H₁₉NO₂SSi 

Relevant articles and documents

BTK Inhibitors and uses thereof

The invention discloses a bruton's tyrosine kinase (BTK) inhibitor and use thereof. Specifically, the invention provides heteroaromatic compounds or stereoisomers, geometrical isomers, tautomers, racemates, nitrogen oxides, hydrates, solvates, metabolites and pharmaceutically acceptable salts or prodrugs thereof, and pharmaceutical compositions containing the heteroaromatic compounds; the invention also discloses use of the heteroaromatic compounds or the pharmaceutical compositions containing the heteroaromatic compounds in preparation of medicines; the medicines can be used for treating autoimmune diseases, inflammatory diseases or proliferative diseases.

Controllable construction of isoquinolinedione and isocoumarin scaffolds: Via RhIII-catalyzed C-H annulation of N -tosylbenzamides with diazo compounds

A highly efficient protocol for the synthesis of isoquinolinediones by RhIII-catalyzed C-H activation/annulation/decarboxylation of N-tosylbenzamides with diazo compounds is reported. The switchable synthesis of isocoumarins was also achieved successfully via C-H activation/annulation with slight modification of the reaction conditions. Importantly, the synthetic utility of this new reaction was further demonstrated in an atom-economical and operationally convenient total synthesis of a TDP2 inhibitor derivative from commercially available starting materials.

Palladium-Catalyzed cascade sp2 c?H bond functionalizations allowing one-Pot access to 4?Aryl-1,2,3,4-tetrahydroquinolines from n?Allyl?N?arylsulfonamides

We have developed a palladium-catalyzed cascade reaction allowing an efficient synthesis of 4-aryl-1,2,3,4-tetrahydroquinolines from N-allyl-N-arylsulfonamides and benzenesulfonyl chlorides. In this transformation, two C(sp2)?C(sp3) bonds were formed via activation of C(sp2)?H bonds. The reaction proceeds using the easily accessible catalyst PdCl2, with Li2CO3 as inexpensive base and CuBr as additive, and tolerates a wide variety of substituents on both reaction partners.