83945-76-0

Basic information

• Product Name: 25-fluoro-22(S)-hydroxycholesterol
• CAS NO: 83945-76-0
• Molecular Weight: 420.652
• Mol File: 83945-76-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 25-fluoro-22(S)-hydroxycholesterol(CAS DataBase Reference)
• NIST Chemistry Reference: 25-fluoro-22(S)-hydroxycholesterol(83945-76-0)
• EPA Substance Registry System: 25-fluoro-22(S)-hydroxycholesterol(83945-76-0)

Safety Data

• Hazardous Substances Data: 83945-76-0(Hazardous Substances Data)

Upstream product

• 79435-62-4 (3β,22S)-cholest-5-ene-3,22-25-triol 3,22-diacetate 
• 76752-38-0 4-chloro-2-methyl-2-<(trimethylsilyl)oxy>butane 
• 63163-38-2 (22S)-cholest-5-ene-3β,22,25-triol 
• 10211-88-8 (20S)-3β-acetoxybisnorchol-5-en-22-al 
• 1985-88-2 4-chloro-2-methyl-2-butanol 
• 93527-43-6 22(S)-acetoxy-25-fluorocholesterol 3-acetate 

Relevant articles and documents

22-Hydroxycholesterol Derivatives as HMG CoA Reductase Suppressors and Serum Cholesterol Lowering Agents

A series of 22-hydroxycholesterol derivatives with a modified side chain terminus was prepared.These agents were evaluated in vitro and in vivo for their ability to suppress HMG CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis.In tissue culture assays, 22-hydroxycholesterol as well as the side chain modified analogues were potent inhibitors of HMG CoA reductase.However, only those sterols with a modified side chain terminus were effective suppressors of liver reductase whene administered ig to rats. 22-Hydroxy-25-methylcholesterol (4a) and 25-fluoro-22-hydroxycholesterol (15a) significantly lowered serum cholesterol levels when administered ig to primates; 25-chloro-22-hydroxycholesterol (15b) and the analogue with a cyclopropyl terminus, 20b, were ineffective.The cholesterol-lowering sterols did not significantly alter lipoprotein levels; however, the two compounds have been shown to inhibit acyl-coenzyme A:cholesterol-transferase (ACAT) in tissue culture studies