83972-61-6

Basic information

• Product Name: 5-hydroxy-Hexanoic acid
• Synonyms: (5R)-5-Hydroxyhexanoic acid
• CAS NO: 83972-61-6
• Molecular Formula: C₆H₁₂O₃
• Molecular Weight: 0
• Mol File: 83972-61-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-hydroxy-Hexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-hydroxy-Hexanoic acid(83972-61-6)
• EPA Substance Registry System: 5-hydroxy-Hexanoic acid(83972-61-6)

Safety Data

• Hazardous Substances Data: 83972-61-6(Hazardous Substances Data)

Upstream product

• 3128-06-1 5-ketohexanoic acid 

Downstream Products

• 43112-32-9 (R)-(+)-δ-methyl-δ-valerolactone 
• 16320-13-1 (S)-6-methyl-tetrahydro-pyran-2-one 

Relevant articles and documents

Chain terminators, the use thereof for nucleic acid sequencing and synthesis and a method of their preparation

The invention relates to compounds of general structure (I) or salts thereof, wherein B is a nucleobase, X and Z independently are oxygen or sulphur, Y is hydrogen or hydroxy, which optionally may be protected, R1 is hydrocarbyl, which optionally is substituted with a functional group, R2 is hydrogen or hydrocarbyl, which optionally is substituted with a functional group, A is an electron withdrawing or electron donating group capable of moderating the acetal stability of compound (I), L1 and L2 are hydrocarbon linkers, which may be the same or different, L2, when present, being either (i) connected to L1 via the group A, or (ii) directly connected to L1, the group A then being connected to one of linkers L1 and L2, F is a dye label, Q is a coupling group for F, and l, m and n independently are 0 or 1, with the proviso that l is 1 when m is 1, and l is 1 and m is 1 when n is 1. The compounds of formula (I) are useful as deactivatable chain extension terminators. The invention also relates to the use of the compounds (I) in nucleic acid synthesis and nucleic acid sequencing as well as to a method of preparing compounds of Formula (I).

Identification of 5-hydroxyhexanoic acid in the urine of twin siblings with a Reye's-like syndrome associated with dicarboxylic aciduria and hypoglycaemia and with similarities to Jamaican vomiting sickness

Twin male infant siblings who presented in Harrow, UK, with a Reye's-like syndrome associated with profound hypoglycaemia, vomiting, diarrhoea, coma and death in one child, with dicarboxylic aciduria, and similarities to Jamaican vomiting sickness (hypoglycin toxicity) have been shown to excrete large amounts of a previously unrecorded urinary organic acid. This has been identified as 5-hydroxyhexanoic acid by gas chromatography mass spectrometry using a synthesized standard. Concentrations observed were 340 and 330 mg g-1 creatinine in the two patients. The metabolic precursor of the urinary acid is suggested to be hex-4-enoic acid, a probable chemical toxin closely related to the active organic acid metabolite of hypoglycin. The possibility of ω-1 oxidation of hexanoic acid to 5-hydroxyhexanoic acid in these and other patients with dicarboxylic acidurias is also discussed.