840-04-0

Basic information

• Product Name: 1H-Pyrrole, 1-methyl-2,5-diphenyl-
• CAS NO: 840-04-0
• Molecular Formula: C17H15N
• Molecular Weight: 233.313
• Mol File: 840-04-0.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole, 1-methyl-2,5-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole, 1-methyl-2,5-diphenyl-(840-04-0)
• EPA Substance Registry System: 1H-Pyrrole, 1-methyl-2,5-diphenyl-(840-04-0)

Safety Data

• Hazardous Substances Data: 840-04-0(Hazardous Substances Data)

Usage

Class

pyrrole derivatives

Structure

1-methyl-2,5-diphenyl-1H-pyrrole

Usage

organic synthesis, pharmaceutical research

Potential applications

drug development, medicinal chemistry

Industrial uses

manufacture of specialty chemicals and materials

Unique properties

the presence of a methyl group and two phenyl groups attached to the pyrrole ring may confer unique chemical and biological activities.

Upstream product

• 1121-07-9 N-methylsuccinimide 
• 74-89-5 methylamine 
• 495-71-6 phenacylacetophenone 
• 729-43-1 acetophenonazine 
• 97405-82-8 2,2,3,3-tetradeuterio-1,4-diphenyl-1,4-butanedione 
• 5044-52-0 vinyltriphenylphosphonium bromide 
• 28544-45-8 N-benzoyl-N-methylphenylglycine 
• 10557-01-4 (E)-N-(α-methylbenzylidene)methylamine 
• 333-27-7 methyl trifluoromethanesulfonate 
• 60-29-7 diethyl ether 
• 71-43-2 benzene 
• 96-54-8 N-Methylpyrrole 
• 108-86-1 bromobenzene 
• 108-90-7 chlorobenzene 

Downstream Products

• 57136-16-0 1-methyl-3-nitro-2,5-diphenyl-pyrrole 
• 101601-59-6 1-methyl-3,4-dinitro-2,5-diphenyl-pyrrole 
• 130850-68-9 3,4-Dibromo-1-methyl-2,5-diphenylpyrrole 
• 127394-94-9 3-amino-2,5-diphenyl-1-methylpyrrole 

Relevant articles and documents

Direct C-H bond activation: Palladium-on-carbon as a reusable heterogeneous catalyst for C-2 arylation of indoles with arylboronic acids

Direct C(sp2)-H bond functionalization of indoles with arylboronic acids is achieved using palladium supported on carbon as a reusable heterogeneous catalyst in the presence of an oxidant under mild conditions. The current protocol formed exclusive C-2 selective products without the aid of any ligand or directing group. The catalyst is reusable for up to four catalytic cycles with the retention of catalytic efficiency.

Synthesis of 2,5-diarylpyrroles by ligand-free palladium-catalyzed ch activation of pyrroles in ionic liquids

The palladium-catalyzed CH activation and arylation of N-methylpyrrole and N-phenylpyrrole allowed a convenient synthesis of diarylpyrroles. The reactions were performed by using tetrabutylammonium acetate as an ionic solvent, which allowed for the application of a ligand-free catalytic system by using simple palladium salts or polyvinylpyrrolidone-stabilized palladium nanoparticles as the catalyst.

Conversion of aryl methyl ketimines to 2,5-diarylpyrroles using TiCl4/Et3N

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