840-78-8

Basic information

• Product Name: 1,2-Bis[(3-pyridinyl)carbonyl]hydrazine
• Synonyms: 1,2-Bis(3-pyridinylcarbonyl)hydrazine;1,2-Bis(nicotinoyl)hydrazine;1,2-Bis[(3-pyridinyl)carbonyl]hydrazine;N,N'-Bis[nicotinic acid]hydrazide
• CAS NO: 840-78-8
• Molecular Formula: C₁₂H₁₀N₄O₂
• Molecular Weight: 0
• Mol File: 840-78-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2-Bis[(3-pyridinyl)carbonyl]hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Bis[(3-pyridinyl)carbonyl]hydrazine(840-78-8)
• EPA Substance Registry System: 1,2-Bis[(3-pyridinyl)carbonyl]hydrazine(840-78-8)

Safety Data

• Hazardous Substances Data: 840-78-8(Hazardous Substances Data)

Usage

Purification Methods

The hydrazide crystallises from water; it is also soluble in hot EtOH but insoluble in *C6H6, pet ether or CHCl3. [Graf J Prakt Chem [2] 138 290 1933, Beilstein 22 III/IV 455.]

Upstream product

• 10400-19-8 3-pyridinecarbonyl chloride 
• 553-53-7 Nicotinic acid hydrazide 
• 100138-75-8 3-nicotinoylhydrazono-butyric acid ethyl ester 
• 101879-06-5 3-nicotinoylhydrazono-3-phenyl-propionic acid ethyl ester 

Downstream Products

• 15362-52-4 2,5-di(3-pyridyl)-1,3,4-thiadiazole 

Relevant articles and documents

OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS

This invention relates to oxadiazolyl and thiadiazolyl derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

Migration of an acyl group in the pyrazole system: Synthesis of 1-acyl-3-hydroxy-1H-pyrazoles and related derivatives. A new preparation of N,N′-diacylhydrazines

A new general method for the synthesis of 1-acyl-3-hydroxy-1H-pyrazoles 5a-f and related derivatives 5g-i starting from 4-ethoxymethylene-2-phenyloxazol-5(4H)-one (1) and hydrazides, 4-phenylsemicarbazide, 4-phenylthiosemicarbazide and benzyl carbazate in boiling dioxane is described. The method includes a migration of an acyl or related unit. The X-ray study and NMR spectroscopic examination confirmed the structure of the products. A one-pot synthesis of N,N′-diacylhydrazines from hydrazides by the assistance of oxazolone 1 is also presented.

STUDIES ON KETENE AND ITS DERIVATIVES. IX. A NEW SYNTHETIC METHOD OF

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