84005-98-1

Basic information

• Product Name: Ethyl morpholine-3-carboxylate hydrochloride
• Synonyms: Ethyl morpholine-3-carboxylate hydrochloride;3-Morpholinecarboxylic acid ethyl ester;Ethyl 3-Morpholinecarboxylate;Ethyl Morpholine-3-carboxylate;3-Morpholinecarboxylic acid ethyl ester HCl
• CAS NO: 84005-98-1
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 196
• Mol File: 84005-98-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 260.5°C at 760 mmHg
• Flash Point: 111.3°C
• Appearance: /
• Density: 1.078±0.06 g/cm3(Predicted)
• Vapor Pressure: 0.00959mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 7.09±0.40(Predicted)
• CAS DataBase Reference: Ethyl morpholine-3-carboxylate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl morpholine-3-carboxylate hydrochloride(84005-98-1)
• EPA Substance Registry System: Ethyl morpholine-3-carboxylate hydrochloride(84005-98-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 84005-98-1(Hazardous Substances Data)

Usage

General Description

Ethyl morpholine-3-carboxylate hydrochloride is a chemical compound that is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs. It is also used as an intermediate in the production of agrochemicals and dyes. Ethyl morpholine-3-carboxylate hydrochloride is a derivative of morpholine, which is a heterocyclic amine containing a six-membered ring with two nitrogen atoms. The hydrochloride salt form of this compound makes it more stable and easier to handle in the laboratory. Overall, ethyl morpholine-3-carboxylate hydrochloride is a versatile chemical that is utilized in the production of a wide range of important products in the pharmaceutical and chemical industries.

InChI:InChI=1/C7H13NO3.ClH/c1-2-11-7(9)6-5-10-4-3-8-6;/h6,8H,2-5H2,1H3;1H

Upstream product

• 77873-76-8 morpholine-3-carboxylic acid 
• 64-17-5 ethanol 
• 75-36-5 acetyl chloride 

Relevant articles and documents

Catalytic Synthesis of N-Unprotected Piperazines, Morpholines, and Thiomorpholines from Aldehydes and SnAP Reagents

Commercially available SnAP (stannyl amine protocol) reagents allow the transformation of aldehydes and ketones into a variety of N-unprotected heterocycles. By identifying new ligands and reaction conditions, a robust catalytic variant that expands the substrate scope to previously inaccessible heteroaromatic substrates and new substitution patterns was realized. It also establishes the basis for a catalytic enantioselective process through the use of chiral ligands. SnAPcat! The identification of new ligands and reaction conditions provides a robust catalytic method for the synthesis of N-unprotected heterocycles using SnAP reagents. This catalytic variant expands the substrate scope to include previously inaccessible piperazines, morpholines, and thiomorpholines and establishes the basis for a catalytic enantioselective process through the use of chiral ligands.

THIADIAZOLES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of Formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and ischemia reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of Formula (IA).

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.