84012-54-4

Basic information

• Product Name: 2-(4-morpholinylmethyl)-1,2-benzisothiazol-3(2H)-one
• Synonyms: 2-(4-morpholinylmethyl)-1,2-benzisothiazol-3(2H)-one;Einecs 281-694-4
• CAS NO: 84012-54-4
• Molecular Formula: C12H14N2O2S
• Molecular Weight: 250.31676
• EINECS: 281-694-4
• Mol File: 84012-54-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 407.2°C at 760 mmHg
• Flash Point: 200°C
• Appearance: /
• Density: 1.333g/cm³
• Vapor Pressure: 7.71E-07mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: 2-(4-morpholinylmethyl)-1,2-benzisothiazol-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-morpholinylmethyl)-1,2-benzisothiazol-3(2H)-one(84012-54-4)
• EPA Substance Registry System: 2-(4-morpholinylmethyl)-1,2-benzisothiazol-3(2H)-one(84012-54-4)

Safety Data

• Hazardous Substances Data: 84012-54-4(Hazardous Substances Data)

Usage

Chemical Class

Benzisothiazolone derivatives

Molecular Weight

290.36 g/mol

Physical Appearance

Solid

Biological Role

Selective 5-HT2B receptor antagonist

Potential Applications

Treatment of disorders related to 5-HT2B receptor, such as cardiovascular diseases and certain psychiatric conditions

Research Uses

Pharmacological studies to elucidate the role of the 5-HT2B receptor in physiological and pathological processes

Additional Potential Uses

Development of new therapeutic agents for specific medical conditions.

InChI:InChI=1/C12H14N2O2S/c15-12-10-3-1-2-4-11(10)17-14(12)9-13-5-7-16-8-6-13/h1-4H,5-9H2

Upstream product

• 110-91-8 morpholine 
• 2634-33-5 1,2-benzisothiazolin-3-one 
• 50-00-0 formaldehyd 
• 7757-82-6 sodium sulfate 

Relevant articles and documents

SMALL MOLECULE OXIDIZERS OF PDI AND THEIR USE

The present invention provides a method for treating or ameliorating the effects of a neurodegenerative disorder in a subject in need thereof comprising administering to the subject an effective amount of a compound selected from the group consisting of combinations thereof, or an N-oxide, crystalline form, hydrate, or pharmaceutically acceptable salt thereof. The present invention also provides a method for treating or ameliorating the effects of a condition associated with increased protein disulfide isomerase (PDI) activity and a method of modulating PDI activity in a cell. The present invention also provides compounds, salts, compositions and kits useful for the provided methods.