84055-96-9Relevant articles and documents
Practical synthesis of 2,3-dimethoxy-5-hydroxymethyl-6-methyl-1,4-benzoquinone
Wang, Jin,Li, Shuo,Yang, Tao,Zeng, Jin-Rong,Yang, Jian
, p. 486 - 489 (2015/02/19)
2,3-dimethoxy-5-hydroxymethyl-6-methyl-1,4-benzoquinone (V) was prepared with a 75 % yield by means of a reaction sequence starting from 2,3,4,5-tetramethoxytoluene via Blanc chloromethylation reaction, Kornblum oxidation, NaBH4 reduction and c
Synthesis and antioxidant activities of Coenzyme Q analogues
Wang, Jin,Li, Shuo,Yang, Tao,Yang, Jian
, p. 710 - 713 (2015/02/19)
A series of 2,3-dimethoxy-5-methyl-1,4-benzoquinones (Coenzyme Q) substituted at the C-6 position with various groups were designed and synthesized based on the Coenzyme Q10 as potent antioxidant. In vitro antioxidant activities of these compounds were evaluated and compared with commercial antioxidant Coenzyme Q10 employing DPPH assay. All these synthesized Coenzyme Q analogues are found to exhibit good antioxidant activities. Of which Compound 8b bearing a N-benzoylpiperazine group at the C-6 position showed more potent inhibition of DPPH radical than Coenzyme Q10. All these results suggested the applicability of the Coenzyme Q analogues as potent antioxidants for combating oxidative stress.
An improved synthesis of the "miracle nutrient" coenzyme Q 10
Lipshutz, Bruce H.,Lower, Asher,Berl, Volker,Schein, Karin,Wetterich, Frank
, p. 4095 - 4097 (2007/10/03)
(Chemical Equation Presented) A new route to the key coupling partner, chloromethylated CoQ0 (1), allows for direct formation of CoQ 10 (3) via nickel-catalyzed cross-coupling with the side chain in the form of an in situ-derived vin