84056-08-6Relevant articles and documents
Site-Selective Linear Alkylation of Anilides by Cooperative Nickel/Aluminum Catalysis
Okumura, Shogo,Komine, Takuya,Shigeki, Erika,Semba, Kazuhiko,Nakao, Yoshiaki
supporting information, p. 929 - 932 (2017/12/26)
We report meta- and para-selective linear alkylation reactions of anilides with alkenes by nickel/N-heterocyclic carbene (NHC) and aluminum catalysis. With a less bulky NHC, the alkylation reaction of N-methyl-N-phenylcyclohexanecarboxamides proceeded mainly at the meta position. In contrast, a bulky NHC ligand led to the para-selective alkylation of N-sec-alkyl anilides.