84100-50-5

Basic information

• Product Name: 4,4-dimethoxypiperidin-3-ol
• Synonyms: 4,4-dimethoxypiperidin-3-ol;Einecs 282-129-4
• CAS NO: 84100-50-5
• Molecular Formula: C₇H₁₅NO₃
• Molecular Weight: 161.1989
• EINECS: 282-129-4
• Mol File: 84100-50-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 242.7°C at 760 mmHg
• Flash Point: 100.6°C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 0.0057mmHg at 25°C
• Refractive Index: 1.478
• CAS DataBase Reference: 4,4-dimethoxypiperidin-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-dimethoxypiperidin-3-ol(84100-50-5)
• EPA Substance Registry System: 4,4-dimethoxypiperidin-3-ol(84100-50-5)

Safety Data

• Hazardous Substances Data: 84100-50-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H15NO3/c1-10-7(11-2)3-4-8-5-6(7)9/h6,8-9H,3-5H2,1-2H3

Upstream product

• 41661-47-6 piperidin-4-one 
• 3240-34-4 [bis(acetoxy)iodo]benzene 

Relevant articles and documents

Prepration of cisapride

Cisapride, i.e. cis-4-amino-5-chloro-N-[1-[3-(4 fluoro-phenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-benzamide, and similar benzamide derivatives, are prepared from novel 1-aryloxyalkyl- or 1-aralkyl-3-arylcarbonyloxy-4-oxo-piperidines, by nuclear substituent re arrangement involving acyl transfer under animal forming conditions, to give the corresponding 1-aryloxyalkyl- or 1-aralkyl-3-hydroxy-4-lower alkoxy-4-arylamido piperidine. This in turn is readily converted to the corresponding 3-oxo-4-arylamido-piperidine by reaction with strong organic acid, which can then be reduced, deprotected and 3-methylated to give the final compound, e.g. cisapride.