84102-89-6

Basic information

• Product Name: Benzonitrile, 4-formyl-3-hydroxy-
• Synonyms: Benzonitrile, 4-formyl-3-hydroxy-;Benzonitrile, 4-formyl-3-hydroxy- (9CI);4-Formyl-3-hydroxybenzonitril;4-Formyl-3-hydroxybenzonitrile;5-Cyano-2-formylphenol, 4-Cyano-2-hydroxybenzaldehyde
• CAS NO: 84102-89-6
• Molecular Formula: C₈H₅NO₂
• Molecular Weight: 147.1308
• Product Categories: ALDEHYDE;Drug Intermediates;Aromatic
• Mol File: 84102-89-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 288.7ºC at 760 mmHg
• Flash Point: 128.4ºC
• Appearance: /
• Density: 1.32 g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: Benzonitrile, 4-formyl-3-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-formyl-3-hydroxy-(84102-89-6)
• EPA Substance Registry System: Benzonitrile, 4-formyl-3-hydroxy-(84102-89-6)

Safety Data

• Hazardous Substances Data: 84102-89-6(Hazardous Substances Data)

Usage

General Description

Benzonitrile, 4-formyl-3-hydroxy- is a chemical compound with the molecular formula C8H7NO2. It is also known as 3-hydroxy-4-formylbenzonitrile and is a white to light yellow crystalline powder. Benzonitrile, 4-formyl-3-hydroxy- is commonly used in the manufacture of pharmaceuticals and can also be used as an intermediate in organic synthesis. It has potential application in the production of dyes, pigments, and other chemical products. Additionally, 4-formyl-3-hydroxy-benzonitrile has been studied for its potential biological and pharmacological activities, although further research is needed to fully understand its properties and potential applications.

InChI:InChI=1/C8H7NO/c1-6-2-3-7(5-9)4-8(6)10/h2-4,10H,1H3

Upstream product

• 84102-88-5 3-Acetoxy-4-(dibrommethyl)benzonitril 
• 3816-66-8 3-hydroxy-4-methylbenzonitrile 
• 84102-87-4 5-cyano-2-methylphenyl acetate 
• 105942-10-7 3-fluoro-4-formylbenzonitrile 
• 21962-45-8 4-formyl-3-methoxy-benzonitrile 
• 4421-08-3 3-methoxy-4-hydroxybenzonitrile 
• 959934-76-0 tert-butyl (2E)-3-(4-cyano-2-methoxyphenyl)acrylate 
• 88328-15-8 4-{[(E)-Pyridin-2-ylmethylimino]-methyl}-benzonitrile 
• 3731-51-9 2-(Aminomethyl)pyridine 
• 105-07-7 4-cyanobenzaldehyde 

Downstream Products

• 84103-00-4 6-Cyan-N-(4-cyanphenyl)-1-benzofuran-2-carboxamid 
• 84103-01-5 6-Amidino-N-(4-amidinophenyl)-1-benzofuran-2-carboxamid-dihydrochlorid 
• 84223-79-0 2-<2-(6-Amidino-1-benzofuran-2-yl)-(E)-vinyl>-1-benzofuran-5-carboxamidin-dihydrochlorid 
• 84223-86-9 2-<2-(6-Amidino-1-benzofuran-2-yl)ethyl>-1-benzofuran-5-carboxamidin-dihydrochlorid 
• 84223-47-2 4',6-Bis(2-imidazolin-2-yl)-1-benzofuran-2-carboxanilid-dihydrochlorid 
• 84102-94-3 <(6-Cyan-2-benzofuran-2-yl)methyl>triphenylphosphoniumchlorid 
• 179254-05-8 3-benzyloxy-4-formylbenzonitrile 
• 959984-36-2 5-cyano-2-formyl-phenyl trifluoromethanesulfonate 
• 202522-04-1 3-ethyl-4-formylbenzonitrile 

Relevant articles and documents

Directed Hydroxylation of sp2 and sp3 C-H Bonds Using Stoichiometric Amounts of Cu and H2O2

The use of copper for C-H bond functionalization, compared to other metals, is relatively unexplored. Herein, we report a synthetic protocol for the regioselective hydroxylation of sp2 and sp3 C-H bonds using a directing group, stoichiometric amounts of Cu and H2O2. A wide array of aromatic ketones and aldehydes are oxidized in the carbonyl γ-position with remarkable yields. We also expanded this methodology to hydroxylate the β-position of alkylic ketones. Spectroscopic characterization, kinetics, and density functional theory calculations point toward the involvement of a mononuclear LCuII(OOH) species, which oxidizes the aromatic sp2 C-H bonds via a concerted heterolytic O-O bond cleavage with concomitant electrophilic attack on the arene system.

SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINES AND USE THEREOF

The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.

Phenylglycine derivatives useful for treating disorders of the central nervous system

A pharmaceutical compound of the formula: STR1 in which R1 is hydrogen, hydroxy or C1-6 alkoxy, R2 is hydrogen, carboxy, tetrazolyl, --SO2 H, --SO3 H, --OSO3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OP(OH)OR' or --OPO(OH)OR' where R' is hydrogen, C1-6 alkyl, C2-6 alkenyl or aryl C1-6 alkyl, R3 is hydrogen, hydroxy or C1-4 alkoxy, and R4 is fluoro, trifluoromethyl, nitro, C1-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkylthio, heteroaryl, optionally substituted aryl, optionally substituted aryl C1-6 alkyl, optionally substituted aryl C2-6 alkenyl, optionally substituted aryl C2-6 alkynyl, optionally substituted aryloxy, optionally substituted aryl C1-6 alkoxy, optionally substituted arylthio, optionally substituted aryl C1-6 alkylthio or --CONR"R'", --SO2 NR"R"", --NR"R'", --OCONR"R"' or --SONR"R'" where R" and R'" are each hydrogen, C1-6 alkyl or aryl C1-6 alkyl, or R" and R'" together form a C3-7 alkylene ring; provided that (i) R1, R2 and R3 are not all hydrogen,and (ii) when R2 and R3 are hydrogen and R1 is hydroxy, R4 is not fluoro; or a salt or ester thereof.