84175-48-4

Basic information

• Product Name: 3-Buten-2-one, 4-[3-(trifluoromethyl)phenyl]-, (3E)-
• CAS NO: 84175-48-4
• Molecular Formula: C11H9F3O
• Molecular Weight: 214.187
• Mol File: 84175-48-4.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 3-Buten-2-one, 4-[3-(trifluoromethyl)phenyl]-, (3E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Buten-2-one, 4-[3-(trifluoromethyl)phenyl]-, (3E)-(84175-48-4)
• EPA Substance Registry System: 3-Buten-2-one, 4-[3-(trifluoromethyl)phenyl]-, (3E)-(84175-48-4)

Safety Data

• Hazardous Substances Data: 84175-48-4(Hazardous Substances Data)

Upstream product

• 779-89-5 3-(trifluoromethyl)cinnamic acid 
• 917-54-4 methyllithium 
• 454-89-7 3-Trifluoromethylbenzaldehyde 
• 67-64-1 acetone 
• 2740-83-2 3-(TRIFLUOROMETHYL)BENZYLAMINE 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 
• 705-28-2 1-ethynyl-3-trifluoromethylbenzene 
• 1439-36-7 1-triphenylphosphoranylidene-2-propanone 

Downstream Products

• 1228699-91-9 (E)-dimethyl 2-hydroxy-4-(3-(trifluoromethyl)phenyl)but-3-en-2-ylphosphonate 
• 1173694-13-7 4-(3-(trifluoromethyl)phenyl)butan-2-amine hydrochloride 
• 84175-35-9 5-(4-morpholinyl)-1-(3-(trifluoromethyl)phenyl)-1-penten-3-one hydrochloride 
• 521267-21-0 5-methyl-3-(3-trifluoromethyl-phenyl)-1H-pyrazole 
• 1442690-00-7 1-(2-(4-fluorobenzoyl)-3-(3-(trifluoromethyl)phenyl)cyclopropyl)ethanone 

Relevant articles and documents

Piperlongumine derivative as well as preparation method and application thereof

The invention discloses a Piperlongumine derivative as well as a preparation method and application thereof. The Piperlongumine derivative has the following structure: the Piperlongumine derivative provided by the invention contains a plurality of Michael addition receptor units, and the novel structure improves the electrophilicity, so that the Piperlongumine derivative has good protein targetingpotential, and the Piperlongumine derivative has a good inhibition effect on thioredoxin reductase; in an antitumor bioactive in-vitro screening experiment, the derivative also has a certain inhibition effect on the growth of tumor cells, and meanwhile, the derivative has an effect of promoting the generation of active oxygen in A549 human lung cancer cells.

Diastereoselective synthesis of β-amino ketone and acid derivatives by palladium-catalyzed conjugate addition

The first diastereoselective synthesis of β-amino ketone and β-amino acid derivatives by palladium-catalyzed conjugate addition of arylboronic acids to chiral β-enamino ketones and β-enamino esters is reported. The catalytic system employing (S)-4-(tert-butyl)oxazolidin-2-one as the chiral auxiliary in water under an air atmosphere provides β-amino ketone and β-amino acid derivatives in high yields with excellent diastereoselectivity.

Rh(III)-Catalyzed Enaminone-Directed Alkenyl C-H Activation for the Synthesis of Salicylaldehydes

A Rh(III)-catalyzed enaminone-directed alkenyl C-H coupling with alkynes for the synthesis of salicylaldehyde derivatives is reported. This represents a unique example of benzene ring framework formation through a transition-metal-catalyzed, directed C-H activation strategy. The two incorporated reactive functionalities, aldehyde and hydroxy groups, provide convenient synthetic handles for further structural elaboration.