84227-69-0 Usage
Description
3-[(diethylaMino)Methyl]phenylMethanaMine, with the molecular formula C13H20N2, is a chemical compound belonging to the amine class of organic compounds. It features a benzene ring with a substituted amine group, which contributes to its unique molecular structure and functional groups. 3-[(diethylaMino)Methyl]phenylMethanaMine is recognized for its potential applications in drug development and medicinal chemistry, making it a valuable asset in pharmaceutical research and organic synthesis.
Uses
Used in Pharmaceutical Research:
3-[(diethylaMino)Methyl]phenylMethanaMine is used as a reagent in pharmaceutical research for its potential applications in drug development. Its unique molecular structure and functional groups make it a promising candidate for the creation of new medications and therapies.
Used in Organic Synthesis:
In the field of organic synthesis, 3-[(diethylaMino)Methyl]phenylMethanaMine serves as a crucial reagent, facilitating the synthesis of various complex organic molecules. Its amine group and benzene ring provide a versatile platform for chemical reactions and modifications, contributing to the development of novel compounds with specific properties and applications.
Used in Drug Development:
3-[(diethylaMino)Methyl]phenylMethanaMine is utilized as a key component in drug development, where its unique structure and functional groups can be leveraged to design and synthesize new pharmaceuticals. Its potential to interact with biological targets and modulate specific pathways makes it a valuable tool in the search for innovative treatments and therapies.
Safety Precautions:
As an amine derivative, 3-[(diethylaMino)Methyl]phenylMethanaMine may possess reactivity and toxicity, necessitating appropriate safety measures during handling and use. It is essential to follow proper guidelines and protocols to minimize risks and ensure the safe application of this compound in research and development settings.
Check Digit Verification of cas no
The CAS Registry Mumber 84227-69-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,2,2 and 7 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 84227-69:
(7*8)+(6*4)+(5*2)+(4*2)+(3*7)+(2*6)+(1*9)=140
140 % 10 = 0
So 84227-69-0 is a valid CAS Registry Number.
84227-69-0Relevant articles and documents
Synthesis of new 4-Aminoquinolines and evaluation of their in vitro activity against chloroquine-sensitive and chloroquine-resistant plasmodium falciparum
Rajapakse, Chandima S.K.,Lisai, Maryna,Deregnaucourt, Christiane,Sinou, Véronique,Latour, Christine,Roy, Dipankar,Schrével, Joseph,Sánchez-Delgado, Roberto A.
, (2015/12/18)
The efficacy of chloroquine, once the drug of choice in the fight against Plasmodium falciparum, is now severely limited due to widespread resistance. Amodiaquine is one of the most potent antimalarial 4-Aminoquinolines known and remains effective against chloroquineresistant parasites, but toxicity issues linked to a quinone-imine metabolite limit its clinical use. In search of new compounds able to retain the antimalarial activity of amodiaquine while circumventing quinone-imine metabolite toxicity, we have synthesized five 4-Aminoquinolines that feature rings lacking hydroxyl groups in the side chain of the molecules and are thus incapable of generating toxic quinone-imines. The new compounds displayed high in vitro potency (low nanomolar IC50), markedly superior to chloroquine and comparable to amodiaquine, against chloroquine-sensitive and chloroquine-resistant strains of P. falciparum, accompanied by low toxicity to L6 rat fibroblasts and MRC5 human lung cells, and metabolic stability comparable or higher than that of amodiaquine. Computational studies indicate a unique mode of binding of compound 4 to heme through the HOMO located on a biphenyl moeity, which may partly explain the high antiplasmodial activity observed for this compound.
