84289-03-2

Basic information

• Product Name: 6,7-dichloroisoquinoline-5,8-dione
• Synonyms: 5,8-isoquinolinedione, 6,7-dichloro-; 6,7-Dichloro-5,8-isoquinolinedione
• CAS NO: 84289-03-2
• Molecular Formula: C₉H₃Cl₂NO₂
• Molecular Weight: 228.0316
• Mol File: 84289-03-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 331.1°C at 760 mmHg
• Flash Point: 154°C
• Density: 1.63g/cm³
• Vapor Pressure: 0.00016mmHg at 25°C
• Refractive Index: 1.639
• CAS DataBase Reference: 6,7-dichloroisoquinoline-5,8-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-dichloroisoquinoline-5,8-dione(84289-03-2)
• EPA Substance Registry System: 6,7-dichloroisoquinoline-5,8-dione(84289-03-2)

Safety Data

• Hazardous Substances Data: 84289-03-2(Hazardous Substances Data)

Upstream product

• 1127-49-7 5,8-diaminoisoquinoline 
• 2439-04-5 5-hydroxyisoquinoline 
• 607-32-9 5-nitroisoquinoline 
• 156901-61-0 8-amino-5-nitro-isoquinoline 
• 1125-60-6 isoquinolin-5-ylamine 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 54879-66-2 acetaldehyde dimethyl acetal 
• 54879-79-7 acetaldehyde dimethyl acetal 
• 1432611-60-3 N-(2,5-dimethoxybenzyl)-N-(2,2-dimethoxyethyl)-2-nitrobenzenesulfonamide 
• 55087-23-5 5,8-dimethoxyisoquinoline 
• 54879-36-6 N-(2,5-dimethoxybenzyl)-N-(2,2-dimethoxyethyl)-4-methylbenzenesulfonamide 
• 54879-54-8 5,8-dimethoxy-3-methyl-2-tosyl-1,2-dihydroisoquinoline 

Downstream Products

• 102072-79-7 6-chloro-7-hydroxy-5,8-isoquinolinedione 
• 228574-27-4 6-chloro-7-((4-methoxyphenyl)amino)isoquinoline-5,8-dione 
• 228574-31-0 6-chloro-7-(2-hydroxyethylphenyl)amino-5,8-isoquinolinedione 
• 296776-09-5 6-chloro-7-(4-isopropylphenyl)amino-5,8-isoquinolinedione 
• 296776-08-4 6-chloro-7-(4-trifluoromethoxyphenyl)amino-5,8-isoquinolinedione 

Relevant articles and documents

Benzoquinone derivative, pharmaceutical composition, and applications thereof

The invention discloses a benzoquinone derivative, a pharmaceutical composition, and applications thereof. According to the invention, the benzoquinone derivative (I), and the stereoisomer or the pharmaceutically acceptable salt thereof possess a structure disclosed in the invention. The benzoquinone derivative possesses excellent inhibition effect on STAT3 level both in vivo and in vitro, and further, the benzoquinone derivative is capable of inhibiting balling capacity of cancer cells.

Exploitation of a tuned oxidation with N -haloimides in the synthesis of caulibugulones A-D

Marine alkaloids caulibugulones A-D were synthesized in six steps starting from the readily available 2,5-dimethoxybenzaldehyde. Pomeranz-Fritsch reaction of N-(2,5-dimethoxybenzyl)-N-(2,2-dimethoxyethyl)-2-nitrobenzenesulfonamide proceeded smoothly to gi

Synthesis, cytotoxic activities and structure-activity relationships of topoisomerase I inhibitors: Indolizinoquinoline-5,12-dione derivatives

A series of indolizinoquinoline-5,12-dione derivatives (IQDs) are synthesized and evaluated for their cytotoxic activities toward human lung adenocarcinoma (GLC-82), large-cell lung carcinoma (NCI-H460), promyelocytic leukemia (HL-60) and breast carcinoma (MCF-7) cells by MTT method. Most of the IQDs show significant cytotoxic potency. In addition, the evaluation of structure-activity relationships indicated that the incorporation of electron-withdrawing substituents at the C or D ring will enhance the activities of the target compounds distinctly. The topoisomerase I inhibitory activity is also measured.