84315-25-3

Basic information

• Product Name: 5,7-Difluoro-2,3-dihydroinden-1-one
• Synonyms: 5,7-Difluoro-1-indanone;5,7-Difluoro-2,3-dihydroinden-1-one;5,7-Difluoro-2,3-dihydro-1H-inden-1-one;1H-Inden-1-one, 5,7-difluoro-2,3-dihydro-;5,7-Difluoro-2,3-dihydro-1H-indene-1-one;5,7-Difluoroindan-1-one
• CAS NO: 84315-25-3
• Molecular Formula: C9H6F2O
• Molecular Weight: 168.14
• Product Categories: Aryl Fluorinated Building Blocks;Building Blocks;C8-C12;C9;Carbonyl Compounds;Chemical Synthesis;Fluorinated Building Blocks;Ketones;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks
• Mol File: 84315-25-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 80-84 °C
• Boiling Point: 251.96 °C at 760 mmHg
• Flash Point: 95.924 °C
• Appearance: /
• Density: 1.362 g/cm³
• Vapor Pressure: 0.02mmHg at 25°C
• Refractive Index: 1.537
• Storage Temp.: 2-8°C
• Water Solubility: Sparingly soluble in water 0.081 g/L 25°C.
• CAS DataBase Reference: 5,7-Difluoro-2,3-dihydroinden-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-Difluoro-2,3-dihydroinden-1-one(84315-25-3)
• EPA Substance Registry System: 5,7-Difluoro-2,3-dihydroinden-1-one(84315-25-3)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-52/53
• Safety Statements: 26-36/37-61
• WGK Germany: 3
• Hazardous Substances Data: 84315-25-3(Hazardous Substances Data)

Usage

Uses

5,7-Difluoro-1-indanone is used as pharmaceutical intermediate.

InChI:InChI=1/C9H6F2O/c10-6-3-5-1-2-8(12)9(5)7(11)4-6/h3-4H,1-2H2

Upstream product

• 84315-24-2 3-(3,5-difluorophenyl)propionic acid 
• 95333-92-9 3-(3,5-difluorophenyl)propionyl chloride 
• 923977-12-2 5-(3,5-difluoro-benzyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 32085-88-4 3,5-difluorobenzaldehyde 
• 461-96-1 3,5-difluorobromobenzene 
• 84315-23-1 3,5-difluorocinnamic acid 

Downstream Products

• 1595028-04-8 8-cyclohexyl-6-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1595028-14-0 8-benzyl-6-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1595028-16-2 8-phenyl-6-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1595028-18-4 8-(4-fluorophenyl)-6-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1595028-20-8 8-(3-fluorophenyl)-6-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1595028-22-0 8-(4-methoxyphenyl)-6-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)-3,4-dihydroisoquinolin-1(2H)-one 

Relevant articles and documents

Synthetic method of 7-fluoro-5-hydroxy-2,3-dihydro-1hydrogen-indene-1-one

The invention relates to a synthetic method of 7-fluoro-5-hydroxy-2,3-dihydro-1hydrogen-indene-1-one. The technical problem that there is no synthetic method suitable for industrialization at present is mainly solved. The synthetic method of the invention

Efficient synthesis of halo indanones via chlorosulfonic acid mediated Friedel-Crafts cyclization of aryl propionic acids and their use in alkylation reactions

Several halo indanones were synthesized from benzyl Meldrum's acid derivatives in two steps. Although several Lewis acids are effective for the Friedel-Crafts ring-closing reaction on more electron-rich arenes, in the case of the electron-deficient arenes this chemistry is not efficient. Here it is reported that chlorosulfonic acid (used as solvent) is an efficient reagent for cyclization of electron-withdrawing arenes. These molecules are potentially useful for subsequent alkylation reactions. The selective alkylation of 5,7-dibromo indanone is demonstrated using Pd-catalyzed Grignard coupling to provide monoalkylated indanone in good yield.

Indanylidenes. 1. Design and synthesis of (E)-2-(4,6-difluoro-1-indanylidene)acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and analgesic activity

The design of rigid cyclic analogues derived from cinnamamide 1, (E)-N-cyclopropyl-3-(3-fluorophenyl)prop-2-enamide, and β-methylcinnamamide 2, (E)-N-cyclopropyl-3-(3-fluorophenyl)but-2-enamide, has led to the discovery of the potent, centrally acting muscle relaxant (E)-2-(4,6-difluoro-1-indanylidene)acetamide, 17. Compound 17 also possesses potent antiinflammatory and analgesic activity. This paper describes the synthesis and the muscle relaxant, antiinflammatory, and analgesic structure-activity relationships of 17 and 67 of its analogues. Compound 17 has been taken into phase I clinical trials.