84331-14-6

Basic information

• Product Name: Ethanone, 1-(6-fluoro-3-pyridinyl)- (9CI)
• Synonyms: Ethanone, 1-(6-fluoro-3-pyridinyl)- (9CI);1-(6-Fluoro-3-pyridinyl)-ethanone;5-Acethyl-2-fluoropyridine;5-Acetyl-2-fluoropyridine;1-(6-Fluoro-3-pyridyl)ethanone;Ethanone, 1-(6-fluoro-3-pyridinyl)-
• CAS NO: 84331-14-6
• Molecular Formula: C₇H₆FNO
• Molecular Weight: 139.1270432
• Product Categories: ACETYLGROUP
• Mol File: 84331-14-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 246.7±20.0℃ (760 Torr)
• Flash Point: 103.0±21.8℃
• Appearance: /
• Density: 1.175±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.027mmHg at 25°C
• Refractive Index: 1.492
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.23±0.10(Predicted)
• CAS DataBase Reference: Ethanone, 1-(6-fluoro-3-pyridinyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(6-fluoro-3-pyridinyl)- (9CI)(84331-14-6)
• EPA Substance Registry System: Ethanone, 1-(6-fluoro-3-pyridinyl)- (9CI)(84331-14-6)

Safety Data

• Hazardous Substances Data: 84331-14-6(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(6-fluoro-3-pyridinyl)- (9CI) is a chemical compound with the molecular formula C7H6FNO. It is a derivative of ethanone with a 6-fluoro-3-pyridinyl group attached. Ethanone, 1-(6-fluoro-3-pyridinyl)- (9CI) is used in the synthesis of pharmaceuticals and agrochemicals. It may also have potential applications in research and development, particularly in the fields of organic chemistry and medicinal chemistry. The specific properties and potential uses of this compound are of interest to chemists and researchers in various industries.

InChI:InChI=1/C7H6FNO/c1-5(10)6-2-3-7(8)9-4-6/h2-4H,1H3

Upstream product

• 774239-06-4 6-fluoro-N-methoxy-N-methylpyridine-3-carboxamide 
• 75-16-1 methylmagnesium bromide 
• 766-11-0 5-bromo-2-fluoropyridine 
• 1034467-37-2 1-(6-fluoropyridin-3-yl)ethan-1-ol 
• 403-45-2 6-fluoronicotinic acid 
• 55676-22-7 3-acetyl-6-chloropyridine 

Downstream Products

• 1450620-30-0 benzyl 4-(5-acetyl-2-pyridinyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate 
• 59229-45-7 1-(6-phenoxypyridine-3-yl)ethan-1-one 
• 1395039-12-9 1-(6-isopropoxypyridin-3-yl)ethan-1-one 

Relevant articles and documents

Modular Synthesis of Alkenyl Sulfamates and β-Ketosulfonamides via Sulfur(VI) Fluoride Exchange (SuFEx) Click Chemistry and Photomediated 1,3-Rearrangement

Herein, we report a synthesis of medicinally relevant β-ketosulfonamides via a photomediated 1,3-rearrangement of alkenyl sulfamates. This protocol tolerates a wide array of sensitive functional groups including alkenes, alkynes, and nitrogen-based heterocycles. Additionally, this work provides a general approach toward alkenyl sulfamates via a two-step Sulfur(VI) Fluoride Exchange (SuFEx) sequence capitalizing on SO2F2 as a linchpin to efficiently couple readily available ketones and amines without a large excess of either partner.

BTK INHIBITOR

Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).

PYRAZOLYLAMINOPYRIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS

This invention relates to novel compounds having the Formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.