84378-44-9 Usage
Description
4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID, 8-FLUORO-5,6-DIHYDRO-5-METHYL-6-OXOis a chemical compound belonging to the imidazo-benzodiazepine class. It is characterized by the presence of an imidazole ring fused to a benzene ring, with a carboxylic acid group attached to the imidazole nitrogen. The molecule also features a fluorine atom at the 8-position, a methyl group at the 5-position, and an oxo group at the 6-position. 4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID, 8-FLUORO-5,6-DIHYDRO-5-METHYL-6-OXOis a derivative of Flumazenil, a benzodiazepine antagonist.
Uses
Used in Pharmaceutical Industry:
4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID, 8-FLUORO-5,6-DIHYDRO-5-METHYL-6-OXOis used as a pharmaceutical compound for its potential therapeutic applications. As a derivative of Flumazenil, it may exhibit antagonistic properties against benzodiazepine receptors, which can be useful in preventing or reversing the effects of benzodiazepines in cases of overdose or dependence.
Used in Research Applications:
4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID, 8-FLUORO-5,6-DIHYDRO-5-METHYL-6-OXOcan also be used in research settings to study the structure-activity relationships of imidazo-benzodiazepines and their interactions with benzodiazepine receptors. This can help in the development of new drugs with improved pharmacological properties and reduced side effects.
Used in Drug Development:
4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID, 8-FLUORO-5,6-DIHYDRO-5-METHYL-6-OXOcan be employed in drug development processes to create novel benzodiazepine antagonists or agonists with specific therapeutic targets. Its unique structural features may provide insights into the design of more effective and safer medications for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 84378-44-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,3,7 and 8 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 84378-44:
(7*8)+(6*4)+(5*3)+(4*7)+(3*8)+(2*4)+(1*4)=159
159 % 10 = 9
So 84378-44-9 is a valid CAS Registry Number.
InChI:InChI=1/C13H10FN3O3/c1-16-5-10-11(13(19)20)15-6-17(10)9-3-2-7(14)4-8(9)12(16)18/h2-4,6H,5H2,1H3,(H,19,20)
84378-44-9Relevant articles and documents
The development of potential new fluorine-18 labelled radiotracers for imaging the GABAA receptor
Jackson, Alexander,Guilbert, Benedicte B.,Plant, Stuart D.,Goggi, Julian,Battle, Mark R.,Woodcraft, John L.,Gaeta, Alessandra,Jones, Clare L.,Bouvet, Denis R.,Jones, Paul A.,O'Shea, Dennis M.,Zheng, Penny Hao,Brown, Samantha L.,Ewan, Amanda L.,Trigg, William
supporting information, p. 821 - 826 (2013/03/13)
Positron emission tomography (PET) using the tracer [11C] Flumazenil has shown changes in the distribution and expression of the GABA A receptor in a range of neurological conditions and injury states. We aim to develop a fluorine-18 labelled PET agent with comparable properties to [11C]Flumazenil. In this study we make a direct comparison between the currently known fluorine-18 labelled GABAA radiotracers and novel imidazobenzodiazepine ligands. A focussed library of novel compound was designed and synthesised where the fluorine containing moiety and the position of attachment is varied. The in vitro affinity of twenty-two compounds for the GABAA receptor was measured. Compounds containing a fluoroalkyl amide or a longer chain ester group were eliminated due to low potency. The fluorine-18 radiochemistry of one compound from each structural type was assessed to confirm that an automated radiosynthesis in good yield was feasible. Eleven of the novel compounds assessed appeared suitable for in vivo assessment as PET tracers.
Characterization of specific drug receptors with fluorescent ligands
-
, (2008/06/13)
Conjugates of fluorescent labels with specific, selective, and high affinity ligands for receptors have been synthesized and used to directly measure binding to receptors. In the examples, fluorescein conjugates of the high-affinity benzodiazepine recepto