84405-38-9Relevant articles and documents
The superbase-mediated pairwise substitution of the 2,2′- and 6,6′-positions in a biphenyl derivative
Schlosser, Manfred,Mangano, Guiseppe,Leroux, Frederic
, p. 1014 - 1017 (2004)
The superbasic mixture of butyllithium and potassium tertbutoxide is powerful enough to enable the double proton abstraction from one ortho and one ortho′ position of 4,4′-di-tert-butylbiphenyl. In this way, a series of functionalized derivatives becomes readily accessible, among them 4,4′-di-tert-butylbiphenyldiyl-2,2′-dicarboxylic acid (2a) and 4,4′-ditert-butylbiphenyl-2,2′-diol (2d). The latter compound can be subjected again to a superbase-promoted double metalation, thus giving rise to 2,2′,6,6′-tetrasubstituted biphenyl derivatives. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
