84409-89-2

Basic information

• Product Name: (2S,5R)-N-[(benzyloxy)carbonyl]-5-hydroxy-2-piperidinecarboxylic acid
• Synonyms: (2S,5R)-N-[(benzyloxy)carbonyl]-5-hydroxy-2-piperidinecarboxylic acid
• CAS NO: 84409-89-2
• Molecular Weight: 279.293
• Mol File: 84409-89-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2S,5R)-N-[(benzyloxy)carbonyl]-5-hydroxy-2-piperidinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5R)-N-[(benzyloxy)carbonyl]-5-hydroxy-2-piperidinecarboxylic acid(84409-89-2)
• EPA Substance Registry System: (2S,5R)-N-[(benzyloxy)carbonyl]-5-hydroxy-2-piperidinecarboxylic acid(84409-89-2)

Safety Data

• Hazardous Substances Data: 84409-89-2(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 50439-45-7 (2S,5R)-5-hydroxy-2-piperidinecarboxylic acid 
• 448964-01-0 (2S)-5-hydroxy-2-piperidinecarboxylic acid 
• 59182-85-3 benzyloxycarbonyl-L-baikiain 
• 147489-30-3 (2S)-5-oxopiperidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester 

Downstream Products

• 50439-45-7 (2S,5R)-5-hydroxy-2-piperidinecarboxylic acid 

Relevant articles and documents

METHOD FOR PRODUCING cis-5-HYDROXY-2-PIPERIDINECARBOXYLIC ACID DERIVATIVE, AND METHOD FOR PURIFYING cis-5-HYDROXY-2-PIPERIDINECARBOXYLIC ACID

The present invention aims to provide a method for purifying cis-5-hydroxy-2-piperidinecarboxylic acid with high purity, and a method for producing its derivative. The present invention provides a method for producing a cis-5-hydroxy-2-piperidinecarboxylic acid derivative, which method comprises a step of converting cis-5-hydroxy-2-piperidinecarboxylic acid into a compound(s) of Formula (1) and/or Formula (2) (wherein R1 represents a protective group for an amino group, and R2 represents a C1-C6 alkyl group), and a method for purifying cis-5-hydroxy-2-piperidinecarboxylic acid.

PREPARATION OF TRANS-5-HYDROXY-L-PIPECOLIC ACID AND CIS-4-HYDROXY-L-PIPECOLIC ACID FROM L-BAIKIAIN (1,2,5,6-L-TETRAHYDROPYRIDINE-2-CARBOXYLIC ACID).

Z-trans-5-OH-L-pipecolic acid together with Z-cis-4-OH-L-pipecolic acid is obtained in a 7:3 ratio by reduction of the oxymercuration product of Z-L-baikiain (Z-1,2,5,6-L-tetrahydropyridine-2-carboxylic acid).The opposite composition ratio is obtained using mercuric trifluoroacetate, thus giving access to the preparation of either of the two isomers.