84445-78-3

Basic information

• Product Name: 1H-Benzimidazole,1-acetyl-5-chloro-(9CI)
• Synonyms: 1H-Benzimidazole,1-acetyl-5-chloro-(9CI)
• CAS NO: 84445-78-3
• Molecular Formula: C₉H₇ClN₂O
• Molecular Weight: 194.62
• Product Categories: BENZIMIDAZOLE
• Mol File: 84445-78-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Benzimidazole,1-acetyl-5-chloro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole,1-acetyl-5-chloro-(9CI)(84445-78-3)
• EPA Substance Registry System: 1H-Benzimidazole,1-acetyl-5-chloro-(9CI)(84445-78-3)

Safety Data

• Hazardous Substances Data: 84445-78-3(Hazardous Substances Data)

Usage

Molecular Weight

197.61 g/mol

Structure

A benzene ring fused to an imidazole ring, with an acetyl group at the first position and a chlorine atom at the fifth position.

Biological Activities

Potential anti-inflammatory and anti-cancer properties.

Upstream product

• 79938-37-7 7-chloro-[1,3]thiazolo[3,2-a]-benzimidazole-3(2H)-one 
• 5443-33-4 N-(5-chloro-2-nitrophenyl)acetamide 

Relevant articles and documents

Synthesis of N-Acetylbenzimidazole Derivatives

For the structure determination of thiazolobenzimidazol-3(2H)-one derivatives (2 or 3) they were converted to the corresponding 1-acetylbenzimidazoles (4) by desulfurization.The latter compounds (4) were alternatively prepared by the cyclization of 2-aminoacetanilide derivatives (5) with CS2 in dimethylformamide (DMF), followed by desulfurization with Raney Ni.However, the reactions of 5 with ethyl orthoformate/H2SO4 in DMF gave a mixture of 4 and its acetyl-rearranged product (7).Keywords-acetyl group; rearrangement; thiazolobenzimidazol-3(2H)-one; N-acetylbenzimidazoles; ethyl orthoformate; carbon disulfide; desulfurization