84449-81-0 Usage
Description
4-(2-PIPERIDIN-1-YLETHOXY)BENZOYL CHLORIDE HYDROCHLORIDE is a chemical compound that serves as a reactant in the synthesis of various pharmaceutical agents. It is characterized by its unique structure, which includes a piperidine ethoxy group attached to a benzoyl chloride moiety, and a hydrochloride counterion. 4-(2-PIPERIDIN-1-YLETHOXY)BENZOYL CHLORIDE HYDROCHLORIDE plays a crucial role in the development of potent revertants targeting P-glycoprotein-associated multidrug resistance (MDR).
Uses
Used in Pharmaceutical Industry:
4-(2-PIPERIDIN-1-YLETHOXY)BENZOYL CHLORIDE HYDROCHLORIDE is used as a reactant for the preparation of highly potent revertants of P-glycoprotein-associated MDR. Its application is crucial in addressing the challenge of multidrug resistance in cancer treatment, as it aids in the development of compounds that can effectively overcome this resistance mechanism.
In the context of cancer treatment, multidrug resistance is a significant issue that arises when cancer cells develop the ability to resist the effects of multiple chemotherapeutic drugs. This resistance is often mediated by the overexpression of P-glycoprotein, a membrane protein that actively pumps drugs out of the cell, reducing their effectiveness. By using 4-(2-PIPERIDIN-1-YLETHOXY)BENZOYL CHLORIDE HYDROCHLORIDE as a reactant, researchers can synthesize potent revertants that counteract the effects of P-glycoprotein, thereby enhancing the efficacy of chemotherapeutic agents and improving treatment outcomes for patients with drug-resistant cancers.
Overall, 4-(2-PIPERIDIN-1-YLETHOXY)BENZOYL CHLORIDE HYDROCHLORIDE is a valuable chemical intermediate in the pharmaceutical industry, particularly for the development of innovative solutions to combat multidrug resistance in cancer therapy. Its unique structure and reactivity make it an essential component in the synthesis of novel and effective anti-cancer agents.
Check Digit Verification of cas no
The CAS Registry Mumber 84449-81-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,4,4 and 9 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 84449-81:
(7*8)+(6*4)+(5*4)+(4*4)+(3*9)+(2*8)+(1*1)=160
160 % 10 = 0
So 84449-81-0 is a valid CAS Registry Number.
84449-81-0Relevant articles and documents
Hepta(methoxycarbonyl)cycloheptatriene halo derivatives
Platonov,Okonnishnikova,Levina,Tomilov, Yu. V.
, p. 241 - 245 (2015/10/05)
A reaction of potassium hepta(methoxycarbonyl)cycloheptatrienide with chlorine and bromine gave high yields of the corresponding chloroand bromohepta(methoxycarbonyl)cycloheptatrienes; the fluoro derivative was obtained by the exchange reaction of the corresponding bromide with silver fluoride. In contrast to the mentioned halides, the iodo derivative has proved unstable. Thermolysis of bromohepta(methoxycarbonyl)cycloheptatriene was studied, as well as its conversion to the azido and methoxy derivatives upon treatment with NaN3 or methanol.
Reaction of stabilised phosphorus ylides with nitrogen dioxide
Aitken, R. Alan,Karodia, Nazira
, p. 251 - 254 (2007/10/03)
The reaction of the stabilised ylides 14-23 with an excess of NO2 in CH2Cl2 at room temperature gives different results depending on the structure of the starting ylide. The monacyl ylides 14-16 give the corresponding α-oxo nitriles 4 together with Ph3PO · HNO3 (24) which has been fully characterised for the first time. Under the same conditions, the ylide 18 gives 2,4-dinitrobenzonitrile (26), Ph3PO, and benzoic acid. The other ylides examined all give 24 together with a variety of other products.
1,2λ3,3λ3-AZADIPHOSPHOLE EIN AROMATISCHES RINGSYSTEM MIT CIS-P=P-DOPPELBINDUNG 1λ3ρ3,λ3ρ3-DIPHOSPHOLE
Maerkl, G.,Dietl, S.,Ziegler, M. L.,Nuber, B.
, p. 5867 - 5870 (2007/10/02)
By reaction of 1,2,4,5-tetrazinedicarboxylates with 4 mole tert-butylphosphaethyne the title compounds are formed in an unusual reaction sequence.
