844694-83-3

Basic information

• Product Name: 5,6-Dimethoxy-2-[(4-piperidyl)methyl]indane (Donepezil Impurity)
• Synonyms: 5,6-Dimethoxy-2-[(4-piperidyl)methyl]indane (Donepezil Impurity);4-[(2,3-Dihydro-5,6-diMethoxy-1H-inden-2-yl)Methyl]piperidine;4-((5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl)piperidine
• CAS NO: 844694-83-3
• Molecular Formula: C₁₇H₂₅NO₂
• Molecular Weight: 275.3859
• Product Categories: Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 844694-83-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 403.1±45.0 °C(Predicted)
• Appearance: /
• Density: 1.048±0.06 g/cm3(Predicted)
• PKA: 10?+-.0.10(Predicted)
• CAS DataBase Reference: 5,6-Dimethoxy-2-[(4-piperidyl)methyl]indane (Donepezil Impurity)(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-Dimethoxy-2-[(4-piperidyl)methyl]indane (Donepezil Impurity)(844694-83-3)
• EPA Substance Registry System: 5,6-Dimethoxy-2-[(4-piperidyl)methyl]indane (Donepezil Impurity)(844694-83-3)

Safety Data

• Hazardous Substances Data: 844694-83-3(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Downstream Products

• 1034439-43-4 5,6-dimethoxy-2-[(4-piperidinyl)methyl]indane hydrochloride 

Relevant articles and documents

A new commercially viable synthetic route for donepezil hydrochloride: Anti-Alzheimer's drug

An economical new process has been developed for the synthesis of donepezil hydrochloride (1) an anti-Alzheimer's drug. The process involves Darzen reaction of pyridine-4-carboxaldehyde and 2-bromo-5,6-dimethoxy indanone affording epoxide 5,6-dimethoxy-3-(pyridine-4-yl)spiro[indene-2,2′-oxiran] -1(3H)-one (4) as a key intermediate. The one-pot deoxygenation of 4 and hydrogenation of the aryl moiety in high yield improved the overall yield of the process.