84478-76-2

Basic information

• Product Name: 1-CHLORO-5-FLUORO-2-METHOXY-4-NITROBENZENE
• Synonyms: 2-CHLORO-4-FLUORO-5-NITROANISOLE;1-CHLORO-5-FLUORO-2-METHOXY-4-NITROBENZENE;4-Chloro-2-fluoro-5-methoxy-1-nitrobenzene;1-Chloro-5-fluoro-2-methoxy-4-nitrobenzene, 2-Chloro-4-fluoro-5-nitrophenyl methyl ether
• CAS NO: 84478-76-2
• Molecular Formula: C₇H₅ClFNO₃
• Molecular Weight: 205.57
• Mol File: 84478-76-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 72-75°C
• Boiling Point: 307.9 °C at 760 mmHg
• Flash Point: 140 °C
• Appearance: /
• Density: 1.453
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-CHLORO-5-FLUORO-2-METHOXY-4-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-5-FLUORO-2-METHOXY-4-NITROBENZENE(84478-76-2)
• EPA Substance Registry System: 1-CHLORO-5-FLUORO-2-METHOXY-4-NITROBENZENE(84478-76-2)

Safety Data

• Hazard Codes: Xi,C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• HazardClass: IRRITANT
• Hazardous Substances Data: 84478-76-2(Hazardous Substances Data)

Usage

General Description

1-CHLORO-5-FLUORO-2-METHOXY-4-NITROBENZENE is a chemical compound that belongs to the class of nitrobenzenes. It is a derivative of benzene with a chlorine, fluorine, methoxy, and nitro group attached to different positions of the benzene ring. 1-CHLORO-5-FLUORO-2-METHOXY-4-NITROBENZENE is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its diverse reactivity and functional groups. It is also known for its potential use as an intermediate in the production of dyes and pigments. However, it is important to handle this chemical with care as it can be harmful if inhaled, ingested, or comes into contact with skin.

Upstream product

• 84478-75-1 2-chloro-4-fluoro-5-nitrophenol 
• 74-88-4 methyl iodide 

Downstream Products

• 14164-14-8 5-chloro-4-methoxy-2-nitrophenol 
• 62257-15-2 2-fluoro-5-methoxyaniline 
• 91167-85-0 4-Chloro-2-fluoro-5-methoxyaniline 
• 1182402-74-9 methyl (5-chloro-4-methoxy-2-nitrophenyl)(2-chlorophenyl)acetate 
• 1182402-76-1 methyl (5-chloro-4-methoxy-2-nitrophenyl)(2-fluorophenyl)acetate 
• 352278-00-3 5-chloro-3-(2-chlorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one 
• 1182402-75-0 5-Chloro-3-(2-fluorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one 
• 1182402-79-4 5-Chloro-3-(4-chlorobutyl)-3-(2-chlorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one 
• 1182402-81-8 5-Chloro-3-(3-chloropropyl)-3-(2-fluorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one 
• 1188354-96-2 tert-Butyl 4-[3-[5-chloro-3-(2-fluorophenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propyl]piperidine-1-carboxylate 
• 1182402-78-3 5-Chloro-3-(2-chlorophenyl)-3-[4-(dimethylamino)butyl]-6-methoxy-1,3-dihydro-2H-indol-2-one 
• 1182402-80-7 5-Chloro-3-(2-fluorophenyl)-3-[3-(dimethylamino)propyl]-6-methoxy-1,3-dihydro-2H-indol-2-one 
• 1182402-84-1 5-Chloro-3-(2-fluorophenyl)-6-methoxy-3-[3-(4-methylpiperazin-1-yl)propyl]-1,3-dihydro-2H-indol-2-one 
• 1188355-33-0 5-Chloro-3-(3-chloropropyl)-3-(2-fluorophenyl)-6-methoxy-1-{[4-(1-methyl-ethoxy)phenyl]sulfonyl}-1,3-dihydro-2H-indol-2-one 

Relevant articles and documents

ANTIBIOTIC COMPOUNDS

The present invention relates to antibiotic compounds of formula (I), to compositions containing these compounds and to methods of treating bacterial diseases and infections using the compounds. The compounds find application in the treatment of infection with, and diseases caused by, Gram-positive and/or Gram-negative bacteria, and in particular in the treatment of infection with, and diseases caused by, Neisseria gonorrhoeae.

Substituted piperazines

Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitors

Novel tricyclics are disclosed together with the use of such compounds for inhibiting SPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.