844891-30-1

Basic information

• Product Name: (2-FLUORO-6-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: (2-FLUORO-6-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER
• CAS NO: 844891-30-1
• Molecular Formula: C₁₂H₁₄FNO₃
• Molecular Weight: 239.24
• Mol File: 844891-30-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-FLUORO-6-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2-FLUORO-6-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER(844891-30-1)
• EPA Substance Registry System: (2-FLUORO-6-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER(844891-30-1)

Safety Data

• Hazardous Substances Data: 844891-30-1(Hazardous Substances Data)

Usage

Description

(2-FLUORO-6-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER is a chemical compound with the molecular formula C12H14FNO3. It is a t-Bu ester of a potentially bioactive carbamic acid derivative, containing a fluoro-substituted aryl group and a formyl group. Its unique structure may contribute to its potential applications in pharmaceutical research and drug development, particularly in the design of therapeutic agents.
Used in Pharmaceutical Research and Drug Development:
(2-FLUORO-6-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER is used as a chemical intermediate for the synthesis of potential therapeutic agents. Its fluoro-substituted aryl group and formyl group may provide unique properties that can be exploited in the development of new drugs.
Used in Medicinal Chemistry:
(2-FLUORO-6-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER is used as a building block in the design and synthesis of novel bioactive compounds. Its structure can be further modified to create new molecules with potential therapeutic applications.
Used in Drug Discovery:
(2-FLUORO-6-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER is used as a starting material in the screening and identification of new drug candidates. Its unique structural features may lead to the discovery of compounds with improved pharmacological properties.
Note: The specific applications and uses of (2-FLUORO-6-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER would require further research and testing to determine its properties and potential in various fields.

Upstream product

• 98968-72-0 tert-butyl 2-fluorophenylcarbamate 
• 68-12-2 N,N-dimethyl-formamide 
• 348-54-9 2-Fluoroaniline 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 854538-98-0 C₁₆H₁₆FN 
• 854538-99-1 {2-Fluoro-6-[(1S,4R)-4,7,7-trimethyl-3-oxo-bicyclo[2.2.1]hept-(2E)-ylidenemethyl]-phenyl}-carbamic acid tert-butyl ester 
• 854539-01-8 {2-[(5S,8R,9S,10S,13S,14S)-10,13-Dimethyl-17-oxo-1,4,5,6,7,8,9,10,11,12,13,14,15,17-tetradecahydro-cyclopenta[a]phenanthren-(16E)-ylidenemethyl]-6-fluoro-phenyl}-carbamic acid tert-butyl ester 
• 854538-94-6 2-amino-3-fluorobenzaldehyde 
• 908600-90-8 tert-butyl 2-[(E)-2-chloroethenyl]-6-fluorophenylcarbamate 
• 387-44-0 7-fluoro-1H-indole 
• 865626-95-5 tert-butyl 2-((1-benzylpiperidin-4-ylamino)methyl)-6-fluorophenylcarbate 

Relevant articles and documents

Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7- methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl) piperidine-1-carboxamide (BMS-694153): A potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure

Calcitonin gene-related peptide (CGRP) has been implicated in the pathogenesis of migraine. Early chemistry leads suffered from modest potency, significant CYP3A4 inhibition, and poor aqueous solubility. Herein, we describe the optimization of these leads to give 4 (BMS-694153), a molecule with outstanding potency, a favorable predictive toxicology profile, and remarkable aqueous solubility. Compound 4 has good intranasal bioavailablity in rabbits and shows dose-dependent activity in validated in vivo and ex vivo migraine models.

Synthesis of regiospecifically substituted quinolines from anilines

A protocol for the synthesis of quinolines substituted on both pyridine and benzo-fused rings is reported. The method is based on the formylation of a substituted N-(tert-butoxycarbonyl)aniline followed by direct cyclisation and aromatisation of the inter

Chiral 5-(diphenylphosphanyl)-1,2,3,4-tetrahydroacridines: New N,P-ligands for asymmetric catalysis

Three chiral 5-(diphenylphosphanyl)-1,2,3,4-tetrahydroacridines, as first representative examples of a new class of chiral N,P-ligands were prepared from (+)-nopinone, (+)-camphor and 5α-androst-2-en-17-one. These ligands have been assessed in the enantioselective palladium-catalysed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethyl malonate. Enantioselectivity up to 74% has been obtained.