845280-54-8

Basic information

• Product Name: 1,3-Dioxane-4-acetic acid, 6-[2-[[1-(4-fluorophenyl)-2-methoxy-2-oxoethyl]amino]ethyl]-2,2-dimethyl -, 1,1-dimethylethyl ester, (4R,6R)-
• CAS NO: 845280-54-8
• Molecular Formula: C23H34FNO6
• Molecular Weight: 439.524
• Mol File: 845280-54-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxane-4-acetic acid, 6-[2-[[1-(4-fluorophenyl)-2-methoxy-2-oxoethyl]amino]ethyl]-2,2-dimethyl -, 1,1-dimethylethyl ester, (4R,6R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxane-4-acetic acid, 6-[2-[[1-(4-fluorophenyl)-2-methoxy-2-oxoethyl]amino]ethyl]-2,2-dimethyl -, 1,1-dimethylethyl ester, (4R,6R)-(845280-54-8)
• EPA Substance Registry System: 1,3-Dioxane-4-acetic acid, 6-[2-[[1-(4-fluorophenyl)-2-methoxy-2-oxoethyl]amino]ethyl]-2,2-dimethyl -, 1,1-dimethylethyl ester, (4R,6R)-(845280-54-8)

Safety Data

• Hazardous Substances Data: 845280-54-8(Hazardous Substances Data)

Upstream product

• 71783-54-5 methyl 2-bromo-2-(4-fluorophenyl)acetate 
• 125971-86-0 tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate 

Downstream Products

• 845280-56-0 {[2-((4R,6R)-6-tert-Butoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-isobutyryl-amino}-(4-fluoro-phenyl)-acetic acid methyl ester 

Relevant articles and documents

Hepatoselectivity of statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors

4-Sulfamoyl pyrroles were designed as novel hepatoselective HMG-CoA reductase inhibitors (statins) to reduce myalgia, a statin-induced adverse effect. The compounds were prepared via a [3 + 2] cycloaddition of a Muenchnone with a sulfonamide-substituted alkyne. We identified compounds with greater selectivity for hepatocytes compared to L6-myocytes than rosuvastatin and atorvastatin. There was an inverse correlation of myocyte potencies and C log P values. A number of analogs were effective at reducing cholesterol in acute and chronic in vivo models but they lacked sufficient chronic in vivo activity to warrant further development.

NOVEL PYRROLE-BASED HMG-COA REDUCTASE INHIBITORS

HMGCo-A reductase inhibitor compounds useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Method of making and methods of using the compounds are also provided.